Human SP121 cell atlas ยท biomarker gene
mechanistic target of rapamycin kinase
Compare the same human-cell UMAP twice: cell-type identity above and MTOR expression below. Matching coordinates make high-expression cell populations directly comparable.
Curated biomarker context
Mechanistic target of rapamycin kinase
Nutrient-sensing kinase; reduced mTOR signaling extends lifespan in multiple model organisms.
PMID 37142830 โmTORC1 activity / inhibition
Inhibition of mTORC1 is associated with lifespan extension in model organisms; interpret mTOR pathway activity and intervention direction separately.
PMID 37142830 โMatched-coordinate comparison
Both panels use the same 20,321 cells and UMAP coordinates. Hover or focus a linked row in the cell-type ranking to highlight that population in both maps.
29 annotated cell types
Colors identify cell types. Labels mark the leading MTOR-expressing populations.
Gray = undetected ยท yellow = high
Color is scaled to the 99th percentile of positive expression so rare outliers do not flatten the visible pattern.
Expression summary
Select a cell name to open its closest standardized LACA cell profile. Images represent that mapped standard cell family while the table retains the atlas subtype label.
| Rank | Cell type | Cells | Mean expression | % expressing | Maximum |
|---|
Values are read directly from the source SP121 H5AD expression matrix and summarized descriptively by annotated cell type. Expression does not establish a causal effect on aging or longevity.