Human SP121 cell atlas ยท biomarker gene
sirtuin 1
Compare the same human-cell UMAP twice: cell-type identity above and SIRT1 expression below. Matching coordinates make high-expression cell populations directly comparable.
Curated biomarker context
Sirtuin 1
Curated longevity-gene record; the linked publication is the evidence record shown in the LACA source table.
PMID 25785999 โSirtuin 1
NAD+-dependent deacetylase linked to metabolism, stress resistance, and caloric-restriction responses.
PMID 32084459 โSirtuin 1 (SIRT1)
NAD+-dependent deacetylase; levels/activity decline with age, implicated in metabolic aging.
PMID 32084459 โMatched-coordinate comparison
Both panels use the same 20,321 cells and UMAP coordinates. Hover or focus a linked row in the cell-type ranking to highlight that population in both maps.
29 annotated cell types
Colors identify cell types. Labels mark the leading SIRT1-expressing populations.
Gray = undetected ยท yellow = high
Color is scaled to the 99th percentile of positive expression so rare outliers do not flatten the visible pattern.
Expression summary
Select a cell name to open its closest standardized LACA cell profile. Images represent that mapped standard cell family while the table retains the atlas subtype label.
| Rank | Cell type | Cells | Mean expression | % expressing | Maximum |
|---|
Values are read directly from the source SP121 H5AD expression matrix and summarized descriptively by annotated cell type. Expression does not establish a causal effect on aging or longevity.