GSM5528615

Dataset: gse182409 • Sample: T119 • Status: Pregnancy-stage cohort
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Quality Control Metrics

96,397,811 Total counts Group median: 70,855,220 • 94.9%ile (↑ High)
33,634 Detected genes Group median: 31,576 • 94.2%ile (↑ High)
0 Mitochondrial fraction (%) Group median: 0 • 94.9%ile (↑ High)

GSE182409 values are from the Chinese-only whole-blood raw count matrix and TMM-normalized logCPM matrix.

Longevity Gene Set (15)

52.6Longevity Score (mean cohort rank, 10/15 genes)
GenePathwayExpression (TMM-logCPM)vs CohortCohort Median%ile
FOXO3 Insulin/IGF-1 Signaling 10.34
bar=donor   line=cohort median 		9.31 98.3%
CETP Lipid Metabolism 1.40
bar=donor   line=cohort median 		1.18 67.2%
SIRT6 Sirtuin Family 2.48
bar=donor   line=cohort median 		2.22 85.9%
SIRT1 Sirtuin Family 5.51
bar=donor   line=cohort median 		5.50 52.8%
SIRT3 Sirtuin Family 2.41
bar=donor   line=cohort median 		2.33 61.7%
IGF1R Insulin/IGF-1 Signaling 6.50
bar=donor   line=cohort median 		7.09 9.3%
KLOTHO Anti-aging 0.31
bar=donor   line=cohort median 		0.66 22.4%
IRS2 Insulin/IGF-1 Signaling 5.77
bar=donor   line=cohort median 		5.59 64.5%
TP53 Tumor Suppression 2.24
bar=donor   line=cohort median 		2.72 22.4%
SHC1 Signal Transduction 3.87
bar=donor   line=cohort median 		3.95 41.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (logCPM)Count
1 ENSG00000265150 ENSG00000265150 15.4 3,754,992
2 ENSG00000258486 ENSG00000258486 15.2 3,282,264
3 7SK ENSG00000202198 misc_RNA 14.7 2,316,571
4 S100A9 ENSG00000163220 protein_coding 13.5 984,646
5 AL355075.4 ENSG00000259001 lncRNA 13.4 956,853
6 MALAT1 ENSG00000251562 lncRNA 13.3 878,270
7 B2M ENSG00000166710 protein_coding 13.3 877,944
8 ALAS2 ENSG00000158578 protein_coding 13.2 784,753
9 NAMPT ENSG00000105835 protein_coding 13.0 681,508
10 BNIP3L ENSG00000104765 protein_coding 12.7 585,225

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 12.1
bar=donor   line=cohort median 		11.8 11.8 77.1%
2 S100A9 protein_coding 13.5
bar=donor   line=cohort median 		13.1 13.1 83.2%
3 IL1B protein_coding 8.0
bar=donor   line=cohort median 		6.9 6.9 98.3%
4 CXCL8 protein_coding 7.8
bar=donor   line=cohort median 		7.6 7.6 60.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.7
bar=donor   line=cohort median 		4.0 4.0 17.5%
6 FCGR3B protein_coding 11.2
bar=donor   line=cohort median 		11.3 11.3 39.4%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 10.1
bar=donor   line=cohort median 		10.9 10.9 8.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 5.4
bar=donor   line=cohort median 		5.3 5.3 57.9%
9 CD3E protein_coding 2.0
bar=donor   line=cohort median 		2.6 2.6 18.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 6.2
bar=donor   line=cohort median 		6.3 6.3 47.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 2.2
bar=donor   line=cohort median 		3.4 3.4 2.4%
12 GNLY protein_coding 4.2
bar=donor   line=cohort median 		4.9 4.9 14.0%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 7.7
bar=donor   line=cohort median 		6.6 6.6 62.7%
14 HBA1 protein_coding 3.4
bar=donor   line=cohort median 		2.6 2.6 59.9%
15 HBA2 protein_coding 6.4
bar=donor   line=cohort median 		5.6 5.6 57.9%
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