GSM6881210

Dataset: gse221521 • Sample: DM group RNA1 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

12,587,957 Total counts Group median: 12,709,871 • 50.5%ile (≈ Median)
26,533 Detected genes Group median: 2,638 • 52.6%ile (≈ Median)
7 Mitochondrial fraction (%) Group median: 6 • 66.6%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

44.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.08
bar=donor   line=cohort median 		0.17 25.1%
FOXO3 Insulin/IGF-1 Signaling 12.91
bar=donor   line=cohort median 		12.92 49.0%
CETP Lipid Metabolism 0.21
bar=donor   line=cohort median 		0.40 8.0%
SIRT6 Sirtuin Family 3.27
bar=donor   line=cohort median 		3.67 27.2%
SIRT1 Sirtuin Family 3.45
bar=donor   line=cohort median 		3.48 46.9%
SIRT3 Sirtuin Family 1.11
bar=donor   line=cohort median 		1.10 51.6%
IGF1R Insulin/IGF-1 Signaling 4.91
bar=donor   line=cohort median 		4.33 60.9%
KLOTHO Anti-aging 0.11
bar=donor   line=cohort median 		0.06 75.4%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.05
bar=donor   line=cohort median 		0.07 39.1%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 57.3%
IRS2 Insulin/IGF-1 Signaling 65.43
bar=donor   line=cohort median 		35.28 85.8%
TP53 Tumor Suppression 3.44
bar=donor   line=cohort median 		3.83 35.5%
SHC1 Signal Transduction 8.11
bar=donor   line=cohort median 		8.77 26.2%
ACE Signal Transduction 0.25
bar=donor   line=cohort median 		0.39 27.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 14,087.7 101,613
2 MT-RNR2 ENSG00000210082 Mt_rRNA 9,551.4 187,443
3 MT-CO1 ENSG00000198804 protein_coding 8,129.2 157,793
4 MT-CO3 ENSG00000198938 protein_coding 6,943.4 68,524
5 MT-CO2 ENSG00000198712 protein_coding 6,798.6 58,537
6 TMSB4XP8 ENSG00000187653 processed_pseudogene 6,484.7 11,020
7 MT-ND3 ENSG00000198840 protein_coding 5,107.6 22,246
8 MT-RNR1 ENSG00000211459 Mt_rRNA 5,037.1 60,490
9 MT-ND1 ENSG00000198888 protein_coding 4,580.9 55,127
10 MT-ND4 ENSG00000198886 protein_coding 4,234.9 73,460

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,516.3
bar=donor   line=cohort median 		1,568.6 1,385.4 54.7%
2 S100A9 protein_coding 14,087.7
bar=donor   line=cohort median 		10,144.6 9,235.1 78.0%
3 IL1B protein_coding 2.9
bar=donor   line=cohort median 		6.9 6.1 15.3%
4 CXCL8 protein_coding 246.2
bar=donor   line=cohort median 		225.8 207.4 56.7%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.9
bar=donor   line=cohort median 		2.2 2.4 14.2%
6 FCGR3B protein_coding 218.4
bar=donor   line=cohort median 		157.0 129.3 82.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 796.7
bar=donor   line=cohort median 		802.6 706.2 58.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 57.2
bar=donor   line=cohort median 		56.8 56.4 51.0%
9 CD3E protein_coding 54.8
bar=donor   line=cohort median 		36.9 37.7 83.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.0
bar=donor   line=cohort median 		3.2 3.1 45.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 500.0
bar=donor   line=cohort median 		296.3 281.6 88.3%
12 GNLY protein_coding 118.7
bar=donor   line=cohort median 		77.5 70.7 82.6%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 448.2
bar=donor   line=cohort median 		509.6 582.1 39.1%
14 HBA1 protein_coding 843.5
bar=donor   line=cohort median 		1,931.5 1,960.7 21.0%
15 HBA2 protein_coding 707.2
bar=donor   line=cohort median 		1,068.0 1,083.5 32.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,129.2
bar=donor   line=cohort median 		7,011.1 6,938.4 69.7%
17 MT-CO2 protein_coding 6,798.6
bar=donor   line=cohort median 		5,968.9 5,810.8 68.1%
18 MT-ND1 protein_coding 4,580.9
bar=donor   line=cohort median 		3,670.4 3,718.2 73.8%
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