GSM6881211

Dataset: gse221521 • Sample: DR group RNA102 • Status: Diabetic retinopathy
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Quality Control Metrics

13,269,337 Total counts Group median: 12,498,211 • 71.8%ile (≈ Median)
26,970 Detected genes Group median: 27,368 • 64.5%ile (≈ Median)
5 Mitochondrial fraction (%) Group median: 6 • 26.2%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

45.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.10
bar=donor   line=cohort median 		0.17 31.4%
FOXO3 Insulin/IGF-1 Signaling 22.13
bar=donor   line=cohort median 		12.92 98.2%
CETP Lipid Metabolism 0.18
bar=donor   line=cohort median 		0.40 6.5%
SIRT6 Sirtuin Family 3.26
bar=donor   line=cohort median 		3.67 26.2%
SIRT1 Sirtuin Family 4.34
bar=donor   line=cohort median 		3.48 78.0%
SIRT3 Sirtuin Family 1.03
bar=donor   line=cohort median 		1.10 38.1%
IGF1R Insulin/IGF-1 Signaling 4.41
bar=donor   line=cohort median 		4.33 51.6%
KLOTHO Anti-aging 0.08
bar=donor   line=cohort median 		0.06 57.3%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.05
bar=donor   line=cohort median 		0.07 37.6%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 66.82
bar=donor   line=cohort median 		35.28 86.8%
TP53 Tumor Suppression 2.94
bar=donor   line=cohort median 		3.83 20.0%
SHC1 Signal Transduction 8.99
bar=donor   line=cohort median 		8.77 58.8%
ACE Signal Transduction 0.28
bar=donor   line=cohort median 		0.39 31.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 12,074.4 91,806
2 MT-RNR2 ENSG00000210082 Mt_rRNA 7,606.4 157,352
3 MT-CO1 ENSG00000198804 protein_coding 6,992.0 143,066
4 TMSB4XP8 ENSG00000187653 processed_pseudogene 4,453.6 7,978
5 MT-RNR1 ENSG00000211459 Mt_rRNA 4,187.8 53,013
6 FTL ENSG00000087086 protein_coding 4,163.7 48,122
7 MT-CO2 ENSG00000198712 protein_coding 4,151.7 37,682
8 MT-CO3 ENSG00000198938 protein_coding 4,038.0 42,008
9 MT-ND4 ENSG00000198886 protein_coding 3,171.2 57,986
10 MT-ND1 ENSG00000198888 protein_coding 2,800.1 35,520

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,784.1
bar=donor   line=cohort median 		1,223.7 1,385.4 68.1%
2 S100A9 protein_coding 12,074.4
bar=donor   line=cohort median 		7,732.1 9,235.1 69.7%
3 IL1B protein_coding 10.2
bar=donor   line=cohort median 		4.9 6.1 78.0%
4 CXCL8 protein_coding 287.1
bar=donor   line=cohort median 		197.4 207.4 63.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 4.1
bar=donor   line=cohort median 		2.9 2.4 78.0%
6 FCGR3B protein_coding 147.7
bar=donor   line=cohort median 		108.9 129.3 57.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 483.2
bar=donor   line=cohort median 		581.4 706.2 25.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 31.0
bar=donor   line=cohort median 		51.6 56.4 8.5%
9 CD3E protein_coding 25.0
bar=donor   line=cohort median 		38.1 37.7 13.7%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 1.7
bar=donor   line=cohort median 		3.0 3.1 11.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 194.7
bar=donor   line=cohort median 		252.2 281.6 24.6%
12 GNLY protein_coding 67.3
bar=donor   line=cohort median 		58.9 70.7 43.8%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 361.5
bar=donor   line=cohort median 		585.0 582.1 29.8%
14 HBA1 protein_coding 1,058.1
bar=donor   line=cohort median 		1,960.4 1,960.7 29.8%
15 HBA2 protein_coding 708.2
bar=donor   line=cohort median 		1,080.5 1,083.5 32.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,992.0
bar=donor   line=cohort median 		6,740.9 6,938.4 51.6%
17 MT-CO2 protein_coding 4,151.7
bar=donor   line=cohort median 		5,693.7 5,810.8 13.7%
18 MT-ND1 protein_coding 2,800.1
bar=donor   line=cohort median 		3,876.8 3,718.2 19.9%
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