GSM6881212

Dataset: gse221521 • Sample: DM group RNA104 • Status: Diabetes mellitus without diabetic retinopathy
◂ Prev All Donors Next ▸

Quality Control Metrics

13,508,610 Total counts Group median: 12,709,871 • 78.5%ile (↑ High)
26,756 Detected genes Group median: 2,638 • 60.4%ile (≈ Median)
7 Mitochondrial fraction (%) Group median: 6 • 76.4%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

45.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.12
bar=donor   line=cohort median 		0.17 37.6%
FOXO3 Insulin/IGF-1 Signaling 14.16
bar=donor   line=cohort median 		12.92 58.8%
CETP Lipid Metabolism 0.49
bar=donor   line=cohort median 		0.40 67.6%
SIRT6 Sirtuin Family 2.44
bar=donor   line=cohort median 		3.67 7.0%
SIRT1 Sirtuin Family 4.43
bar=donor   line=cohort median 		3.48 81.1%
SIRT3 Sirtuin Family 0.86
bar=donor   line=cohort median 		1.10 13.2%
IGF1R Insulin/IGF-1 Signaling 5.54
bar=donor   line=cohort median 		4.33 70.7%
KLOTHO Anti-aging 0.06
bar=donor   line=cohort median 		0.06 41.7%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.01
bar=donor   line=cohort median 		0.01 40.2%
IRS2 Insulin/IGF-1 Signaling 33.94
bar=donor   line=cohort median 		35.28 47.9%
TP53 Tumor Suppression 3.97
bar=donor   line=cohort median 		3.83 54.7%
SHC1 Signal Transduction 8.77
bar=donor   line=cohort median 		8.77 50.5%
ACE Signal Transduction 0.39
bar=donor   line=cohort median 		0.39 50.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 9,498.3 200,034
2 MT-CO1 ENSG00000198804 protein_coding 8,818.1 183,683
3 MT-ATP6 ENSG00000198899 protein_coding 7,638.8 70,272
4 MT-ND4 ENSG00000198886 protein_coding 6,422.6 119,556
5 S100A9 ENSG00000163220 protein_coding 6,244.4 48,334
6 MT-CO2 ENSG00000198712 protein_coding 6,131.1 56,651
7 MT-ND4L ENSG00000212907 protein_coding 5,432.9 21,797
8 TMSB4XP8 ENSG00000187653 processed_pseudogene 5,045.9 9,202
9 MT-ATP8 ENSG00000228253 protein_coding 4,366.5 12,210
10 MT-ND1 ENSG00000198888 protein_coding 4,045.5 52,244

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 916.7
bar=donor   line=cohort median 		1,568.6 1,385.4 18.9%
2 S100A9 protein_coding 6,244.4
bar=donor   line=cohort median 		10,144.6 9,235.1 24.6%
3 IL1B protein_coding 5.9
bar=donor   line=cohort median 		6.9 6.1 49.5%
4 CXCL8 protein_coding 313.0
bar=donor   line=cohort median 		225.8 207.4 68.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 4.0
bar=donor   line=cohort median 		2.2 2.4 76.9%
6 FCGR3B protein_coding 117.5
bar=donor   line=cohort median 		157.0 129.3 40.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 680.9
bar=donor   line=cohort median 		802.6 706.2 46.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 27.8
bar=donor   line=cohort median 		56.8 56.4 5.4%
9 CD3E protein_coding 27.1
bar=donor   line=cohort median 		36.9 37.7 18.9%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.3
bar=donor   line=cohort median 		3.2 3.1 54.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 283.2
bar=donor   line=cohort median 		296.3 281.6 51.6%
12 GNLY protein_coding 173.4
bar=donor   line=cohort median 		77.5 70.7 94.6%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 714.5
bar=donor   line=cohort median 		509.6 582.1 58.3%
14 HBA1 protein_coding 3,613.4
bar=donor   line=cohort median 		1,931.5 1,960.7 69.7%
15 HBA2 protein_coding 1,062.4
bar=donor   line=cohort median 		1,068.0 1,083.5 47.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,818.1
bar=donor   line=cohort median 		7,011.1 6,938.4 81.6%
17 MT-CO2 protein_coding 6,131.1
bar=donor   line=cohort median 		5,968.9 5,810.8 57.3%
18 MT-ND1 protein_coding 4,045.5
bar=donor   line=cohort median 		3,670.4 3,718.2 59.8%
◂ Previous Donor Back to Donor List Next Donor ▸