GSM6881213

Dataset: gse221521 • Sample: DM group RNA108 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

12,436,089 Total counts Group median: 12,709,871 • 42.7%ile (≈ Median)
26,427 Detected genes Group median: 2,638 • 47.9%ile (≈ Median)
5 Mitochondrial fraction (%) Group median: 6 • 28.2%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

46.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.21
bar=donor   line=cohort median 		0.17 65.5%
FOXO3 Insulin/IGF-1 Signaling 15.52
bar=donor   line=cohort median 		12.92 69.7%
CETP Lipid Metabolism 0.21
bar=donor   line=cohort median 		0.40 9.6%
SIRT6 Sirtuin Family 3.49
bar=donor   line=cohort median 		3.67 40.2%
SIRT1 Sirtuin Family 4.48
bar=donor   line=cohort median 		3.48 82.1%
SIRT3 Sirtuin Family 1.07
bar=donor   line=cohort median 		1.10 43.3%
IGF1R Insulin/IGF-1 Signaling 2.51
bar=donor   line=cohort median 		4.33 26.7%
KLOTHO Anti-aging 0.02
bar=donor   line=cohort median 		0.06 21.5%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.06
bar=donor   line=cohort median 		0.07 49.5%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 47.37
bar=donor   line=cohort median 		35.28 67.6%
TP53 Tumor Suppression 3.73
bar=donor   line=cohort median 		3.83 46.9%
SHC1 Signal Transduction 8.22
bar=donor   line=cohort median 		8.77 30.3%
ACE Signal Transduction 0.52
bar=donor   line=cohort median 		0.39 73.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 12,465.6 88,828
2 MT-RNR2 ENSG00000210082 Mt_rRNA 7,296.8 141,469
3 MT-CO1 ENSG00000198804 protein_coding 6,980.1 133,853
4 TMSB4XP8 ENSG00000187653 processed_pseudogene 5,451.3 9,152
5 MT-CO2 ENSG00000198712 protein_coding 5,229.7 44,485
6 MT-CO3 ENSG00000198938 protein_coding 5,047.4 49,212
7 FTL ENSG00000087086 protein_coding 4,995.9 54,115
8 MT-ND4 ENSG00000198886 protein_coding 3,511.2 60,171
9 MT-RNR1 ENSG00000211459 Mt_rRNA 3,488.9 41,393
10 H3P6 ENSG00000235655 processed_pseudogene 2,960.5 15,132

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,750.1
bar=donor   line=cohort median 		1,568.6 1,385.4 66.1%
2 S100A9 protein_coding 12,465.6
bar=donor   line=cohort median 		10,144.6 9,235.1 74.4%
3 IL1B protein_coding 13.6
bar=donor   line=cohort median 		6.9 6.1 89.4%
4 CXCL8 protein_coding 233.1
bar=donor   line=cohort median 		225.8 207.4 54.7%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 9.0
bar=donor   line=cohort median 		2.2 2.4 93.0%
6 FCGR3B protein_coding 294.8
bar=donor   line=cohort median 		157.0 129.3 94.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 706.2
bar=donor   line=cohort median 		802.6 706.2 50.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 34.3
bar=donor   line=cohort median 		56.8 56.4 13.2%
9 CD3E protein_coding 29.3
bar=donor   line=cohort median 		36.9 37.7 23.6%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.4
bar=donor   line=cohort median 		3.2 3.1 58.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 135.6
bar=donor   line=cohort median 		296.3 281.6 8.5%
12 GNLY protein_coding 39.3
bar=donor   line=cohort median 		77.5 70.7 16.3%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 156.8
bar=donor   line=cohort median 		509.6 582.1 9.6%
14 HBA1 protein_coding 650.5
bar=donor   line=cohort median 		1,931.5 1,960.7 13.7%
15 HBA2 protein_coding 578.2
bar=donor   line=cohort median 		1,068.0 1,083.5 28.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,980.1
bar=donor   line=cohort median 		7,011.1 6,938.4 50.5%
17 MT-CO2 protein_coding 5,229.7
bar=donor   line=cohort median 		5,968.9 5,810.8 33.9%
18 MT-ND1 protein_coding 2,936.4
bar=donor   line=cohort median 		3,670.4 3,718.2 23.6%
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