GSM6881214

Dataset: gse221521 • Sample: Control group RNA109 • Status: Healthy control
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Quality Control Metrics

12,505,909 Total counts Group median: 12,762,148 • 46.4%ile (≈ Median)
27,120 Detected genes Group median: 2,606 • 69.7%ile (≈ Median)
5 Mitochondrial fraction (%) Group median: 6 • 27.7%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

49.5Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.15
bar=donor   line=cohort median 		0.17 45.9%
FOXO3 Insulin/IGF-1 Signaling 15.42
bar=donor   line=cohort median 		12.92 67.6%
CETP Lipid Metabolism 0.45
bar=donor   line=cohort median 		0.40 61.4%
SIRT6 Sirtuin Family 4.02
bar=donor   line=cohort median 		3.67 67.6%
SIRT1 Sirtuin Family 4.07
bar=donor   line=cohort median 		3.48 72.8%
SIRT3 Sirtuin Family 1.00
bar=donor   line=cohort median 		1.10 32.4%
IGF1R Insulin/IGF-1 Signaling 4.61
bar=donor   line=cohort median 		4.33 53.6%
KLOTHO Anti-aging 0.04
bar=donor   line=cohort median 		0.06 27.7%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.18
bar=donor   line=cohort median 		0.07 86.8%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 46.78
bar=donor   line=cohort median 		35.28 66.6%
TP53 Tumor Suppression 3.32
bar=donor   line=cohort median 		3.83 31.9%
SHC1 Signal Transduction 8.23
bar=donor   line=cohort median 		8.77 31.4%
ACE Signal Transduction 0.26
bar=donor   line=cohort median 		0.39 29.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 12,200.9 87,430
2 MT-RNR2 ENSG00000210082 Mt_rRNA 7,601.3 148,200
3 MT-CO1 ENSG00000198804 protein_coding 5,444.7 104,996
4 FTL ENSG00000087086 protein_coding 5,398.0 58,798
5 TMSB4XP8 ENSG00000187653 processed_pseudogene 5,063.1 8,548
6 MT-CO3 ENSG00000198938 protein_coding 4,752.0 46,592
7 MT-RNR1 ENSG00000211459 Mt_rRNA 4,475.5 53,396
8 MT-CO2 ENSG00000198712 protein_coding 4,399.0 37,629
9 MT-ND1 ENSG00000198888 protein_coding 4,011.4 47,959
10 MT-ND3 ENSG00000198840 protein_coding 3,467.5 15,004

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,838.7
bar=donor   line=cohort median 		1,535.8 1,385.4 69.7%
2 S100A9 protein_coding 12,200.9
bar=donor   line=cohort median 		10,851.3 9,235.1 71.2%
3 IL1B protein_coding 12.5
bar=donor   line=cohort median 		5.6 6.1 85.2%
4 CXCL8 protein_coding 257.4
bar=donor   line=cohort median 		220.4 207.4 59.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.2
bar=donor   line=cohort median 		1.7 2.4 46.9%
6 FCGR3B protein_coding 211.6
bar=donor   line=cohort median 		145.0 129.3 80.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 592.6
bar=donor   line=cohort median 		709.1 706.2 37.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 41.7
bar=donor   line=cohort median 		66.1 56.4 26.2%
9 CD3E protein_coding 33.8
bar=donor   line=cohort median 		37.6 37.7 37.6%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 4.0
bar=donor   line=cohort median 		3.1 3.1 70.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 160.0
bar=donor   line=cohort median 		302.3 281.6 15.3%
12 GNLY protein_coding 23.2
bar=donor   line=cohort median 		80.1 70.7 4.4%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 146.3
bar=donor   line=cohort median 		598.7 582.1 8.5%
14 HBA1 protein_coding 424.5
bar=donor   line=cohort median 		2,133.6 1,960.7 4.4%
15 HBA2 protein_coding 411.4
bar=donor   line=cohort median 		1,142.2 1,083.5 15.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,444.7
bar=donor   line=cohort median 		6,862.1 6,938.4 19.9%
17 MT-CO2 protein_coding 4,399.0
bar=donor   line=cohort median 		6,023.6 5,810.8 15.3%
18 MT-ND1 protein_coding 4,011.4
bar=donor   line=cohort median 		3,656.3 3,718.2 57.8%
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