GSM6881216

Dataset: gse221521 • Sample: DM group RNA110 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

13,312,786 Total counts Group median: 12,709,871 • 73.8%ile (≈ Median)
25,097 Detected genes Group median: 2,638 • 14.2%ile (↓ Low)
6 Mitochondrial fraction (%) Group median: 6 • 50.5%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

33.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.08
bar=donor   line=cohort median 		0.17 22.0%
FOXO3 Insulin/IGF-1 Signaling 9.28
bar=donor   line=cohort median 		12.92 17.9%
CETP Lipid Metabolism 0.23
bar=donor   line=cohort median 		0.40 11.7%
SIRT6 Sirtuin Family 5.04
bar=donor   line=cohort median 		3.67 91.5%
SIRT1 Sirtuin Family 2.67
bar=donor   line=cohort median 		3.48 13.2%
SIRT3 Sirtuin Family 1.13
bar=donor   line=cohort median 		1.10 55.7%
IGF1R Insulin/IGF-1 Signaling 0.47
bar=donor   line=cohort median 		4.33 2.3%
KLOTHO Anti-aging 0.00
bar=donor   line=cohort median 		0.06 5.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 19.74
bar=donor   line=cohort median 		35.28 16.8%
TP53 Tumor Suppression 3.88
bar=donor   line=cohort median 		3.83 52.1%
SHC1 Signal Transduction 8.58
bar=donor   line=cohort median 		8.77 43.3%
ACE Signal Transduction 0.97
bar=donor   line=cohort median 		0.39 95.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 19,006.5 144,986
2 MT-RNR2 ENSG00000210082 Mt_rRNA 10,501.2 217,948
3 FTL ENSG00000087086 protein_coding 7,308.4 84,744
4 TMSB4XP8 ENSG00000187653 processed_pseudogene 7,301.3 13,122
5 MT-CO2 ENSG00000198712 protein_coding 6,832.2 62,214
6 MT-RNR1 ENSG00000211459 Mt_rRNA 6,571.4 83,459
7 MT-CO1 ENSG00000198804 protein_coding 6,309.9 129,532
8 MT-CO3 ENSG00000198938 protein_coding 6,193.9 64,647
9 MT-ND1 ENSG00000198888 protein_coding 3,861.2 49,142
10 MT-ND3 ENSG00000198840 protein_coding 3,685.4 16,976

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,346.4
bar=donor   line=cohort median 		1,568.6 1,385.4 84.7%
2 S100A9 protein_coding 19,006.5
bar=donor   line=cohort median 		10,144.6 9,235.1 92.5%
3 IL1B protein_coding 17.3
bar=donor   line=cohort median 		6.9 6.1 93.0%
4 CXCL8 protein_coding 201.2
bar=donor   line=cohort median 		225.8 207.4 47.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.8
bar=donor   line=cohort median 		2.2 2.4 10.6%
6 FCGR3B protein_coding 241.2
bar=donor   line=cohort median 		157.0 129.3 87.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,101.3
bar=donor   line=cohort median 		802.6 706.2 79.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 67.4
bar=donor   line=cohort median 		56.8 56.4 65.5%
9 CD3E protein_coding 35.7
bar=donor   line=cohort median 		36.9 37.7 44.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.0
bar=donor   line=cohort median 		3.2 3.1 15.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 444.2
bar=donor   line=cohort median 		296.3 281.6 82.6%
12 GNLY protein_coding 102.6
bar=donor   line=cohort median 		77.5 70.7 71.2%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 677.3
bar=donor   line=cohort median 		509.6 582.1 56.7%
14 HBA1 protein_coding 1,960.7
bar=donor   line=cohort median 		1,931.5 1,960.7 50.0%
15 HBA2 protein_coding 2,138.9
bar=donor   line=cohort median 		1,068.0 1,083.5 74.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,309.9
bar=donor   line=cohort median 		7,011.1 6,938.4 36.0%
17 MT-CO2 protein_coding 6,832.2
bar=donor   line=cohort median 		5,968.9 5,810.8 68.7%
18 MT-ND1 protein_coding 3,861.2
bar=donor   line=cohort median 		3,670.4 3,718.2 54.1%
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