GSM6881217

Dataset: gse221521 • Sample: DM group RNA114 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

14,291,339 Total counts Group median: 12,709,871 • 85.8%ile (↑ High)
26,260 Detected genes Group median: 2,638 • 42.2%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 43.8%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

48.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.04
bar=donor   line=cohort median 		0.17 14.3%
FOXO3 Insulin/IGF-1 Signaling 15.14
bar=donor   line=cohort median 		12.92 65.0%
CETP Lipid Metabolism 0.48
bar=donor   line=cohort median 		0.40 67.1%
SIRT6 Sirtuin Family 2.87
bar=donor   line=cohort median 		3.67 14.3%
SIRT1 Sirtuin Family 5.37
bar=donor   line=cohort median 		3.48 93.5%
SIRT3 Sirtuin Family 1.09
bar=donor   line=cohort median 		1.10 49.0%
IGF1R Insulin/IGF-1 Signaling 5.52
bar=donor   line=cohort median 		4.33 70.2%
KLOTHO Anti-aging 0.29
bar=donor   line=cohort median 		0.06 98.7%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.04
bar=donor   line=cohort median 		0.07 36.5%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 52.1%
IRS2 Insulin/IGF-1 Signaling 37.90
bar=donor   line=cohort median 		35.28 56.7%
TP53 Tumor Suppression 3.02
bar=donor   line=cohort median 		3.83 21.5%
SHC1 Signal Transduction 8.34
bar=donor   line=cohort median 		8.77 34.5%
ACE Signal Transduction 0.15
bar=donor   line=cohort median 		0.39 7.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 9,235.1 75,626
2 MT-RNR2 ENSG00000210082 Mt_rRNA 8,109.6 180,683
3 MT-CO1 ENSG00000198804 protein_coding 7,361.4 162,224
4 TMSB4XP8 ENSG00000187653 processed_pseudogene 5,784.4 11,160
5 MT-CO2 ENSG00000198712 protein_coding 5,176.1 50,598
6 MT-ATP6 ENSG00000198899 protein_coding 5,108.7 49,720
7 FTL ENSG00000087086 protein_coding 4,715.2 58,694
8 MT-CO3 ENSG00000198938 protein_coding 4,193.2 46,982
9 MT-RNR1 ENSG00000211459 Mt_rRNA 4,127.7 56,277
10 MT-ND4 ENSG00000198886 protein_coding 3,764.3 74,132

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,713.2
bar=donor   line=cohort median 		1,568.6 1,385.4 63.5%
2 S100A9 protein_coding 9,235.1
bar=donor   line=cohort median 		10,144.6 9,235.1 50.0%
3 IL1B protein_coding 18.6
bar=donor   line=cohort median 		6.9 6.1 93.5%
4 CXCL8 protein_coding 106.9
bar=donor   line=cohort median 		225.8 207.4 21.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 9.9
bar=donor   line=cohort median 		2.2 2.4 94.6%
6 FCGR3B protein_coding 216.6
bar=donor   line=cohort median 		157.0 129.3 82.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 730.7
bar=donor   line=cohort median 		802.6 706.2 53.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 28.3
bar=donor   line=cohort median 		56.8 56.4 6.5%
9 CD3E protein_coding 23.6
bar=donor   line=cohort median 		36.9 37.7 12.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.3
bar=donor   line=cohort median 		3.2 3.1 27.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 145.0
bar=donor   line=cohort median 		296.3 281.6 11.7%
12 GNLY protein_coding 56.4
bar=donor   line=cohort median 		77.5 70.7 33.9%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 256.2
bar=donor   line=cohort median 		509.6 582.1 22.0%
14 HBA1 protein_coding 675.3
bar=donor   line=cohort median 		1,931.5 1,960.7 14.8%
15 HBA2 protein_coding 525.2
bar=donor   line=cohort median 		1,068.0 1,083.5 24.1%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,361.4
bar=donor   line=cohort median 		7,011.1 6,938.4 57.3%
17 MT-CO2 protein_coding 5,176.1
bar=donor   line=cohort median 		5,968.9 5,810.8 32.9%
18 MT-ND1 protein_coding 3,458.8
bar=donor   line=cohort median 		3,670.4 3,718.2 39.1%
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