GSM6881218

Dataset: gse221521 • Sample: DM group RNA115 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

12,823,678 Total counts Group median: 12,709,871 • 57.3%ile (≈ Median)
24,677 Detected genes Group median: 2,638 • 9.6%ile (↓ Low)
6 Mitochondrial fraction (%) Group median: 6 • 53.6%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

37.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.06
bar=donor   line=cohort median 		0.17 18.4%
FOXO3 Insulin/IGF-1 Signaling 6.89
bar=donor   line=cohort median 		12.92 8.0%
CETP Lipid Metabolism 0.40
bar=donor   line=cohort median 		0.40 52.1%
SIRT6 Sirtuin Family 5.33
bar=donor   line=cohort median 		3.67 96.6%
SIRT1 Sirtuin Family 3.66
bar=donor   line=cohort median 		3.48 61.9%
SIRT3 Sirtuin Family 1.33
bar=donor   line=cohort median 		1.10 82.1%
IGF1R Insulin/IGF-1 Signaling 0.39
bar=donor   line=cohort median 		4.33 0.8%
KLOTHO Anti-aging 0.05
bar=donor   line=cohort median 		0.06 38.1%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 8.41
bar=donor   line=cohort median 		35.28 6.0%
TP53 Tumor Suppression 5.41
bar=donor   line=cohort median 		3.83 84.7%
SHC1 Signal Transduction 8.04
bar=donor   line=cohort median 		8.77 23.6%
ACE Signal Transduction 0.14
bar=donor   line=cohort median 		0.39 5.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 12,447.0 91,460
2 MT-RNR2 ENSG00000210082 Mt_rRNA 8,592.2 171,776
3 MT-CO1 ENSG00000198804 protein_coding 8,016.6 158,521
4 MT-CO2 ENSG00000198712 protein_coding 7,778.2 68,226
5 TMSB4XP8 ENSG00000187653 processed_pseudogene 7,149.4 12,377
6 MT-CO3 ENSG00000198938 protein_coding 7,038.7 70,765
7 HBA1 ENSG00000206172 protein_coding 6,169.9 136,087
8 MT-ND3 ENSG00000198840 protein_coding 5,364.9 23,804
9 MT-RNR1 ENSG00000211459 Mt_rRNA 5,332.8 65,240
10 FTL ENSG00000087086 protein_coding 5,161.9 57,656

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,863.8
bar=donor   line=cohort median 		1,568.6 1,385.4 71.2%
2 S100A9 protein_coding 12,447.0
bar=donor   line=cohort median 		10,144.6 9,235.1 73.3%
3 IL1B protein_coding 9.9
bar=donor   line=cohort median 		6.9 6.1 76.4%
4 CXCL8 protein_coding 55.3
bar=donor   line=cohort median 		225.8 207.4 9.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 4.8
bar=donor   line=cohort median 		2.2 2.4 80.1%
6 FCGR3B protein_coding 215.3
bar=donor   line=cohort median 		157.0 129.3 81.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 722.7
bar=donor   line=cohort median 		802.6 706.2 52.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 129.9
bar=donor   line=cohort median 		56.8 56.4 96.6%
9 CD3E protein_coding 52.6
bar=donor   line=cohort median 		36.9 37.7 80.6%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 1.3
bar=donor   line=cohort median 		3.2 3.1 7.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 798.4
bar=donor   line=cohort median 		296.3 281.6 98.7%
12 GNLY protein_coding 117.2
bar=donor   line=cohort median 		77.5 70.7 81.6%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,243.8
bar=donor   line=cohort median 		509.6 582.1 79.0%
14 HBA1 protein_coding 6,169.9
bar=donor   line=cohort median 		1,931.5 1,960.7 84.7%
15 HBA2 protein_coding 4,477.4
bar=donor   line=cohort median 		1,068.0 1,083.5 90.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,016.6
bar=donor   line=cohort median 		7,011.1 6,938.4 67.6%
17 MT-CO2 protein_coding 7,778.2
bar=donor   line=cohort median 		5,968.9 5,810.8 76.9%
18 MT-ND1 protein_coding 3,108.6
bar=donor   line=cohort median 		3,670.4 3,718.2 29.3%
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