GSM6881219

Dataset: gse221521 • Sample: DR group RNA116 • Status: Diabetic retinopathy
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Quality Control Metrics

12,583,766 Total counts Group median: 12,498,211 • 50.0%ile (≈ Median)
25,797 Detected genes Group median: 27,368 • 26.7%ile (≈ Median)
7 Mitochondrial fraction (%) Group median: 6 • 73.3%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

37.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.17 4.9%
FOXO3 Insulin/IGF-1 Signaling 12.83
bar=donor   line=cohort median 		12.92 46.4%
CETP Lipid Metabolism 0.39
bar=donor   line=cohort median 		0.40 48.5%
SIRT6 Sirtuin Family 2.15
bar=donor   line=cohort median 		3.67 4.4%
SIRT1 Sirtuin Family 6.04
bar=donor   line=cohort median 		3.48 96.6%
SIRT3 Sirtuin Family 1.05
bar=donor   line=cohort median 		1.10 40.2%
IGF1R Insulin/IGF-1 Signaling 4.77
bar=donor   line=cohort median 		4.33 56.7%
KLOTHO Anti-aging 0.01
bar=donor   line=cohort median 		0.06 15.3%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.05
bar=donor   line=cohort median 		0.07 39.6%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 23.40
bar=donor   line=cohort median 		35.28 22.5%
TP53 Tumor Suppression 5.40
bar=donor   line=cohort median 		3.83 83.7%
SHC1 Signal Transduction 7.66
bar=donor   line=cohort median 		8.77 13.2%
ACE Signal Transduction 0.21
bar=donor   line=cohort median 		0.39 17.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-CO1 ENSG00000198804 protein_coding 9,149.6 177,540
2 MT-RNR2 ENSG00000210082 Mt_rRNA 8,806.9 172,774
3 MT-ATP6 ENSG00000198899 protein_coding 8,537.1 73,159
4 TMSB4XP8 ENSG00000187653 processed_pseudogene 7,627.1 12,957
5 MT-CO2 ENSG00000198712 protein_coding 6,781.5 58,370
6 S100A9 ENSG00000163220 protein_coding 6,036.3 43,525
7 MT-ND4 ENSG00000198886 protein_coding 5,104.7 88,517
8 FTL ENSG00000087086 protein_coding 4,899.9 53,705
9 MT-ND1 ENSG00000198888 protein_coding 4,311.3 51,865
10 MT-ATP8 ENSG00000228253 protein_coding 4,216.0 10,982

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 817.4
bar=donor   line=cohort median 		1,223.7 1,385.4 14.8%
2 S100A9 protein_coding 6,036.3
bar=donor   line=cohort median 		7,732.1 9,235.1 22.5%
3 IL1B protein_coding 13.1
bar=donor   line=cohort median 		4.9 6.1 86.3%
4 CXCL8 protein_coding 118.1
bar=donor   line=cohort median 		197.4 207.4 24.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.2
bar=donor   line=cohort median 		2.9 2.4 47.9%
6 FCGR3B protein_coding 404.5
bar=donor   line=cohort median 		108.9 129.3 97.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 792.7
bar=donor   line=cohort median 		581.4 706.2 58.3%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 37.5
bar=donor   line=cohort median 		51.6 56.4 18.9%
9 CD3E protein_coding 34.8
bar=donor   line=cohort median 		38.1 37.7 42.7%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.4
bar=donor   line=cohort median 		3.0 3.1 59.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 222.3
bar=donor   line=cohort median 		252.2 281.6 30.3%
12 GNLY protein_coding 80.4
bar=donor   line=cohort median 		58.9 70.7 57.3%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 495.8
bar=donor   line=cohort median 		585.0 582.1 44.3%
14 HBA1 protein_coding 2,293.5
bar=donor   line=cohort median 		1,960.4 1,960.7 56.7%
15 HBA2 protein_coding 1,110.7
bar=donor   line=cohort median 		1,080.5 1,083.5 52.1%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 9,149.6
bar=donor   line=cohort median 		6,740.9 6,938.4 85.8%
17 MT-CO2 protein_coding 6,781.5
bar=donor   line=cohort median 		5,693.7 5,810.8 67.6%
18 MT-ND1 protein_coding 4,311.3
bar=donor   line=cohort median 		3,876.8 3,718.2 68.1%
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