GSM6881221

Dataset: gse221521 • Sample: Control group RNA117 • Status: Healthy control
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Quality Control Metrics

12,110,242 Total counts Group median: 12,762,148 • 31.3%ile (≈ Median)
25,086 Detected genes Group median: 2,606 • 13.7%ile (↓ Low)
8 Mitochondrial fraction (%) Group median: 6 • 85.8%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

44.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.11
bar=donor   line=cohort median 		0.17 35.0%
FOXO3 Insulin/IGF-1 Signaling 12.50
bar=donor   line=cohort median 		12.92 43.3%
CETP Lipid Metabolism 0.43
bar=donor   line=cohort median 		0.40 59.3%
SIRT6 Sirtuin Family 3.46
bar=donor   line=cohort median 		3.67 38.1%
SIRT1 Sirtuin Family 3.65
bar=donor   line=cohort median 		3.48 60.9%
SIRT3 Sirtuin Family 0.88
bar=donor   line=cohort median 		1.10 14.8%
IGF1R Insulin/IGF-1 Signaling 0.53
bar=donor   line=cohort median 		4.33 3.9%
KLOTHO Anti-aging 0.10
bar=donor   line=cohort median 		0.06 70.7%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.03
bar=donor   line=cohort median 		0.07 32.4%
TERT Telomere Maintenance 0.01
bar=donor   line=cohort median 		0.01 46.4%
IRS2 Insulin/IGF-1 Signaling 33.88
bar=donor   line=cohort median 		35.28 47.4%
TP53 Tumor Suppression 3.51
bar=donor   line=cohort median 		3.83 38.1%
SHC1 Signal Transduction 8.94
bar=donor   line=cohort median 		8.77 56.7%
ACE Signal Transduction 0.48
bar=donor   line=cohort median 		0.39 65.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 11,853.2 223,787
2 MT-CO2 ENSG00000198712 protein_coding 9,294.2 76,988
3 MT-CO1 ENSG00000198804 protein_coding 8,999.5 168,057
4 TMSB4XP8 ENSG00000187653 processed_pseudogene 8,214.0 13,429
5 MT-ATP6 ENSG00000198899 protein_coding 8,116.7 66,939
6 S100A9 ENSG00000163220 protein_coding 7,861.5 54,552
7 MT-RNR1 ENSG00000211459 Mt_rRNA 6,611.9 76,388
8 MT-CO3 ENSG00000198938 protein_coding 6,548.1 62,170
9 MT-ND1 ENSG00000198888 protein_coding 6,242.1 72,267
10 FTL ENSG00000087086 protein_coding 5,325.5 56,173

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,373.5
bar=donor   line=cohort median 		1,535.8 1,385.4 48.4%
2 S100A9 protein_coding 7,861.5
bar=donor   line=cohort median 		10,851.3 9,235.1 39.6%
3 IL1B protein_coding 6.2
bar=donor   line=cohort median 		5.6 6.1 53.1%
4 CXCL8 protein_coding 545.6
bar=donor   line=cohort median 		220.4 207.4 91.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.8
bar=donor   line=cohort median 		1.7 2.4 38.6%
6 FCGR3B protein_coding 121.3
bar=donor   line=cohort median 		145.0 129.3 44.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,089.8
bar=donor   line=cohort median 		709.1 706.2 78.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 59.2
bar=donor   line=cohort median 		66.1 56.4 54.1%
9 CD3E protein_coding 50.6
bar=donor   line=cohort median 		37.6 37.7 77.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.8
bar=donor   line=cohort median 		3.1 3.1 41.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 281.9
bar=donor   line=cohort median 		302.3 281.6 50.5%
12 GNLY protein_coding 98.0
bar=donor   line=cohort median 		80.1 70.7 68.7%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 790.7
bar=donor   line=cohort median 		598.7 582.1 63.0%
14 HBA1 protein_coding 5,157.0
bar=donor   line=cohort median 		2,133.6 1,960.7 79.0%
15 HBA2 protein_coding 3,146.9
bar=donor   line=cohort median 		1,142.2 1,083.5 82.1%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,999.5
bar=donor   line=cohort median 		6,862.1 6,938.4 83.7%
17 MT-CO2 protein_coding 9,294.2
bar=donor   line=cohort median 		6,023.6 5,810.8 87.3%
18 MT-ND1 protein_coding 6,242.1
bar=donor   line=cohort median 		3,656.3 3,718.2 90.9%
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