GSM6881222

Dataset: gse221521 • Sample: Control group RNA124 • Status: Healthy control
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Quality Control Metrics

13,204,140 Total counts Group median: 12,762,148 • 69.7%ile (≈ Median)
22,926 Detected genes Group median: 2,606 • 3.4%ile (↓ Low)
3 Mitochondrial fraction (%) Group median: 6 • 0.8%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

35.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.14
bar=donor   line=cohort median 		0.17 44.8%
FOXO3 Insulin/IGF-1 Signaling 13.32
bar=donor   line=cohort median 		12.92 53.1%
CETP Lipid Metabolism 0.23
bar=donor   line=cohort median 		0.40 12.7%
SIRT6 Sirtuin Family 5.21
bar=donor   line=cohort median 		3.67 95.1%
SIRT1 Sirtuin Family 1.33
bar=donor   line=cohort median 		3.48 0.8%
SIRT3 Sirtuin Family 0.85
bar=donor   line=cohort median 		1.10 12.2%
IGF1R Insulin/IGF-1 Signaling 2.41
bar=donor   line=cohort median 		4.33 25.7%
KLOTHO Anti-aging 0.07
bar=donor   line=cohort median 		0.06 53.1%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.03
bar=donor   line=cohort median 		0.01 78.5%
IRS2 Insulin/IGF-1 Signaling 51.57
bar=donor   line=cohort median 		35.28 74.9%
TP53 Tumor Suppression 1.46
bar=donor   line=cohort median 		3.83 0.8%
SHC1 Signal Transduction 6.75
bar=donor   line=cohort median 		8.77 4.4%
ACE Signal Transduction 0.24
bar=donor   line=cohort median 		0.39 23.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 22,280.8 168,576
2 FTL ENSG00000087086 protein_coding 6,973.7 80,203
3 HBA1 ENSG00000206172 protein_coding 6,086.1 138,222
4 TMSB4XP8 ENSG00000187653 processed_pseudogene 5,819.7 10,374
5 MT-RNR2 ENSG00000210082 Mt_rRNA 5,247.3 108,018
6 MT-RNR1 ENSG00000211459 Mt_rRNA 4,026.2 50,717
7 MT-CO2 ENSG00000198712 protein_coding 4,019.5 36,303
8 HBA2 ENSG00000188536 protein_coding 3,968.9 88,462
9 MT-CO1 ENSG00000198804 protein_coding 3,070.0 62,507
10 RPL13AP5 ENSG00000236552 processed_pseudogene 2,977.0 24,057

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,132.7
bar=donor   line=cohort median 		1,535.8 1,385.4 81.1%
2 S100A9 protein_coding 22,280.8
bar=donor   line=cohort median 		10,851.3 9,235.1 96.6%
3 IL1B protein_coding 5.7
bar=donor   line=cohort median 		5.6 6.1 47.9%
4 CXCL8 protein_coding 208.0
bar=donor   line=cohort median 		220.4 207.4 50.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 7.2
bar=donor   line=cohort median 		1.7 2.4 87.8%
6 FCGR3B protein_coding 158.5
bar=donor   line=cohort median 		145.0 129.3 62.4%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 867.4
bar=donor   line=cohort median 		709.1 706.2 64.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 61.7
bar=donor   line=cohort median 		66.1 56.4 58.3%
9 CD3E protein_coding 32.0
bar=donor   line=cohort median 		37.6 37.7 31.9%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 1.7
bar=donor   line=cohort median 		3.1 3.1 10.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 297.7
bar=donor   line=cohort median 		302.3 281.6 55.2%
12 GNLY protein_coding 105.1
bar=donor   line=cohort median 		80.1 70.7 72.8%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,216.7
bar=donor   line=cohort median 		598.7 582.1 78.0%
14 HBA1 protein_coding 6,086.1
bar=donor   line=cohort median 		2,133.6 1,960.7 83.7%
15 HBA2 protein_coding 3,968.9
bar=donor   line=cohort median 		1,142.2 1,083.5 86.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 3,070.0
bar=donor   line=cohort median 		6,862.1 6,938.4 1.3%
17 MT-CO2 protein_coding 4,019.5
bar=donor   line=cohort median 		6,023.6 5,810.8 12.2%
18 MT-ND1 protein_coding 1,468.7
bar=donor   line=cohort median 		3,656.3 3,718.2 3.4%
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