GSM6881223

Dataset: gse221521 • Sample: DM group RNA126 • Status: Diabetes mellitus without diabetic retinopathy
◂ Prev All Donors Next ▸

Quality Control Metrics

12,467,365 Total counts Group median: 12,709,871 • 44.3%ile (≈ Median)
24,266 Detected genes Group median: 2,638 • 7.0%ile (↓ Low)
4 Mitochondrial fraction (%) Group median: 6 • 6.0%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

39.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.17 4.9%
FOXO3 Insulin/IGF-1 Signaling 17.92
bar=donor   line=cohort median 		12.92 84.2%
CETP Lipid Metabolism 0.28
bar=donor   line=cohort median 		0.40 23.6%
SIRT6 Sirtuin Family 1.45
bar=donor   line=cohort median 		3.67 2.3%
SIRT1 Sirtuin Family 5.55
bar=donor   line=cohort median 		3.48 95.1%
SIRT3 Sirtuin Family 1.28
bar=donor   line=cohort median 		1.10 74.4%
IGF1R Insulin/IGF-1 Signaling 3.04
bar=donor   line=cohort median 		4.33 34.5%
KLOTHO Anti-aging 0.04
bar=donor   line=cohort median 		0.06 28.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.08
bar=donor   line=cohort median 		0.07 57.3%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 43.18
bar=donor   line=cohort median 		35.28 61.9%
TP53 Tumor Suppression 3.68
bar=donor   line=cohort median 		3.83 45.3%
SHC1 Signal Transduction 7.05
bar=donor   line=cohort median 		8.77 6.0%
ACE Signal Transduction 0.13
bar=donor   line=cohort median 		0.39 4.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 7,394.5 52,825
2 MT-RNR2 ENSG00000210082 Mt_rRNA 7,197.1 139,888
3 MT-CO1 ENSG00000198804 protein_coding 7,096.0 136,418
4 TMSB4XP8 ENSG00000187653 processed_pseudogene 5,888.0 9,910
5 EEF1A1P5 ENSG00000196205 processed_pseudogene 3,862.8 66,892
6 RPS28P7 ENSG00000227097 processed_pseudogene 3,811.1 9,978
7 HBA1 ENSG00000206172 protein_coding 3,177.3 68,133
8 H3P6 ENSG00000235655 processed_pseudogene 3,089.3 15,830
9 FTL ENSG00000087086 protein_coding 2,917.4 31,680
10 RPL13AP5 ENSG00000236552 processed_pseudogene 2,561.6 19,545

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,176.5
bar=donor   line=cohort median 		1,568.6 1,385.4 36.0%
2 S100A9 protein_coding 7,394.5
bar=donor   line=cohort median 		10,144.6 9,235.1 35.0%
3 IL1B protein_coding 10.9
bar=donor   line=cohort median 		6.9 6.1 82.1%
4 CXCL8 protein_coding 799.4
bar=donor   line=cohort median 		225.8 207.4 95.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 3.6
bar=donor   line=cohort median 		2.2 2.4 73.3%
6 FCGR3B protein_coding 201.0
bar=donor   line=cohort median 		157.0 129.3 75.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,180.0
bar=donor   line=cohort median 		802.6 706.2 81.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 49.6
bar=donor   line=cohort median 		56.8 56.4 39.6%
9 CD3E protein_coding 29.7
bar=donor   line=cohort median 		36.9 37.7 25.6%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 13.7
bar=donor   line=cohort median 		3.2 3.1 97.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 134.6
bar=donor   line=cohort median 		296.3 281.6 8.0%
12 GNLY protein_coding 115.5
bar=donor   line=cohort median 		77.5 70.7 79.5%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 395.8
bar=donor   line=cohort median 		509.6 582.1 34.5%
14 HBA1 protein_coding 3,177.3
bar=donor   line=cohort median 		1,931.5 1,960.7 66.1%
15 HBA2 protein_coding 1,073.7
bar=donor   line=cohort median 		1,068.0 1,083.5 49.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,096.0
bar=donor   line=cohort median 		7,011.1 6,938.4 53.1%
17 MT-CO2 protein_coding 2,358.0
bar=donor   line=cohort median 		5,968.9 5,810.8 2.3%
18 MT-ND1 protein_coding 1,265.8
bar=donor   line=cohort median 		3,670.4 3,718.2 2.3%
◂ Previous Donor Back to Donor List Next Donor ▸