GSM6881224

Dataset: gse221521 • Sample: DM group RNA132 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

12,725,523 Total counts Group median: 12,709,871 • 53.6%ile (≈ Median)
25,614 Detected genes Group median: 2,638 • 22.5%ile (↓ Low)
10 Mitochondrial fraction (%) Group median: 6 • 93.5%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

54.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.10
bar=donor   line=cohort median 		0.17 32.4%
FOXO3 Insulin/IGF-1 Signaling 11.19
bar=donor   line=cohort median 		12.92 30.8%
CETP Lipid Metabolism 0.24
bar=donor   line=cohort median 		0.40 16.3%
SIRT6 Sirtuin Family 3.37
bar=donor   line=cohort median 		3.67 32.4%
SIRT1 Sirtuin Family 4.92
bar=donor   line=cohort median 		3.48 88.3%
SIRT3 Sirtuin Family 1.27
bar=donor   line=cohort median 		1.10 73.3%
IGF1R Insulin/IGF-1 Signaling 4.87
bar=donor   line=cohort median 		4.33 60.4%
KLOTHO Anti-aging 0.00
bar=donor   line=cohort median 		0.06 5.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.16
bar=donor   line=cohort median 		0.07 85.2%
TERT Telomere Maintenance 0.06
bar=donor   line=cohort median 		0.01 93.5%
IRS2 Insulin/IGF-1 Signaling 29.51
bar=donor   line=cohort median 		35.28 40.2%
TP53 Tumor Suppression 5.06
bar=donor   line=cohort median 		3.83 80.1%
SHC1 Signal Transduction 9.04
bar=donor   line=cohort median 		8.77 60.4%
ACE Signal Transduction 0.55
bar=donor   line=cohort median 		0.39 76.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 12,787.9 253,701
2 MT-CO1 ENSG00000198804 protein_coding 11,469.6 225,066
3 MT-ATP6 ENSG00000198899 protein_coding 10,957.3 94,957
4 MT-CO2 ENSG00000198712 protein_coding 9,331.6 81,225
5 TMSB4XP8 ENSG00000187653 processed_pseudogene 7,298.8 12,539
6 MT-ND4 ENSG00000198886 protein_coding 7,107.6 124,638
7 MT-ND1 ENSG00000198888 protein_coding 7,037.5 85,615
8 MT-CO3 ENSG00000198938 protein_coding 6,509.0 64,939
9 MT-RNR1 ENSG00000211459 Mt_rRNA 6,081.7 73,833
10 MT-ATP8 ENSG00000228253 protein_coding 5,886.8 15,507

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 484.6
bar=donor   line=cohort median 		1,568.6 1,385.4 6.0%
2 S100A9 protein_coding 3,756.5
bar=donor   line=cohort median 		10,144.6 9,235.1 11.1%
3 IL1B protein_coding 4.9
bar=donor   line=cohort median 		6.9 6.1 40.2%
4 CXCL8 protein_coding 380.1
bar=donor   line=cohort median 		225.8 207.4 78.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 3.0
bar=donor   line=cohort median 		2.2 2.4 63.0%
6 FCGR3B protein_coding 118.5
bar=donor   line=cohort median 		157.0 129.3 41.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,197.4
bar=donor   line=cohort median 		802.6 706.2 82.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 51.8
bar=donor   line=cohort median 		56.8 56.4 44.8%
9 CD3E protein_coding 47.0
bar=donor   line=cohort median 		36.9 37.7 72.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 7.0
bar=donor   line=cohort median 		3.2 3.1 91.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 162.7
bar=donor   line=cohort median 		296.3 281.6 15.8%
12 GNLY protein_coding 48.3
bar=donor   line=cohort median 		77.5 70.7 25.1%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 264.9
bar=donor   line=cohort median 		509.6 582.1 23.1%
14 HBA1 protein_coding 1,576.5
bar=donor   line=cohort median 		1,931.5 1,960.7 39.6%
15 HBA2 protein_coding 700.5
bar=donor   line=cohort median 		1,068.0 1,083.5 31.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 11,469.6
bar=donor   line=cohort median 		7,011.1 6,938.4 95.6%
17 MT-CO2 protein_coding 9,331.6
bar=donor   line=cohort median 		5,968.9 5,810.8 88.3%
18 MT-ND1 protein_coding 7,037.5
bar=donor   line=cohort median 		3,670.4 3,718.2 95.1%
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