GSM6881225

Dataset: gse221521 • Sample: Control group RNA133 • Status: Healthy control
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Quality Control Metrics

14,896,700 Total counts Group median: 12,762,148 • 90.9%ile (↑ High)
27,592 Detected genes Group median: 2,606 • 80.1%ile (↑ High)
5 Mitochondrial fraction (%) Group median: 6 • 33.9%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

45.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.09
bar=donor   line=cohort median 		0.17 28.8%
FOXO3 Insulin/IGF-1 Signaling 10.65
bar=donor   line=cohort median 		12.92 26.7%
CETP Lipid Metabolism 0.38
bar=donor   line=cohort median 		0.40 45.3%
SIRT6 Sirtuin Family 4.43
bar=donor   line=cohort median 		3.67 81.1%
SIRT1 Sirtuin Family 2.51
bar=donor   line=cohort median 		3.48 9.6%
SIRT3 Sirtuin Family 1.08
bar=donor   line=cohort median 		1.10 45.9%
IGF1R Insulin/IGF-1 Signaling 3.51
bar=donor   line=cohort median 		4.33 40.7%
KLOTHO Anti-aging 0.07
bar=donor   line=cohort median 		0.06 54.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.23
bar=donor   line=cohort median 		0.07 91.5%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 22.22
bar=donor   line=cohort median 		35.28 21.0%
TP53 Tumor Suppression 4.53
bar=donor   line=cohort median 		3.83 68.7%
SHC1 Signal Transduction 8.78
bar=donor   line=cohort median 		8.77 51.0%
ACE Signal Transduction 0.35
bar=donor   line=cohort median 		0.39 43.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 21,923.5 187,135
2 MT-RNR2 ENSG00000210082 Mt_rRNA 7,758.7 180,188
3 MT-CO1 ENSG00000198804 protein_coding 6,569.3 150,901
4 FTL ENSG00000087086 protein_coding 6,064.7 78,690
5 MT-CO3 ENSG00000198938 protein_coding 5,381.1 62,846
6 MT-CO2 ENSG00000198712 protein_coding 5,297.7 53,980
7 MT-RNR1 ENSG00000211459 Mt_rRNA 4,552.1 64,692
8 MT-ND3 ENSG00000198840 protein_coding 4,136.8 21,322
9 TMSB4XP8 ENSG00000187653 processed_pseudogene 3,507.6 7,054
10 MT-ND1 ENSG00000198888 protein_coding 3,436.0 48,933

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 3,113.5
bar=donor   line=cohort median 		1,535.8 1,385.4 95.1%
2 S100A9 protein_coding 21,923.5
bar=donor   line=cohort median 		10,851.3 9,235.1 95.1%
3 IL1B protein_coding 10.7
bar=donor   line=cohort median 		5.6 6.1 81.1%
4 CXCL8 protein_coding 178.7
bar=donor   line=cohort median 		220.4 207.4 40.7%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 4.0
bar=donor   line=cohort median 		1.7 2.4 75.9%
6 FCGR3B protein_coding 187.7
bar=donor   line=cohort median 		145.0 129.3 72.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,202.6
bar=donor   line=cohort median 		709.1 706.2 82.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 68.0
bar=donor   line=cohort median 		66.1 56.4 66.1%
9 CD3E protein_coding 37.3
bar=donor   line=cohort median 		37.6 37.7 49.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.8
bar=donor   line=cohort median 		3.1 3.1 65.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 248.3
bar=donor   line=cohort median 		302.3 281.6 39.6%
12 GNLY protein_coding 79.1
bar=donor   line=cohort median 		80.1 70.7 55.7%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 314.8
bar=donor   line=cohort median 		598.7 582.1 27.2%
14 HBA1 protein_coding 1,298.9
bar=donor   line=cohort median 		2,133.6 1,960.7 36.0%
15 HBA2 protein_coding 843.0
bar=donor   line=cohort median 		1,142.2 1,083.5 41.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,569.3
bar=donor   line=cohort median 		6,862.1 6,938.4 41.2%
17 MT-CO2 protein_coding 5,297.7
bar=donor   line=cohort median 		6,023.6 5,810.8 34.5%
18 MT-ND1 protein_coding 3,436.0
bar=donor   line=cohort median 		3,656.3 3,718.2 38.6%
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