GSM6881227

Dataset: gse221521 • Sample: DR group RNA140 • Status: Diabetic retinopathy
◂ Prev All Donors Next ▸

Quality Control Metrics

13,104,206 Total counts Group median: 12,498,211 • 66.6%ile (≈ Median)
28,499 Detected genes Group median: 27,368 • 94.0%ile (↑ High)
6 Mitochondrial fraction (%) Group median: 6 • 61.9%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

51.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.18
bar=donor   line=cohort median 		0.17 55.7%
FOXO3 Insulin/IGF-1 Signaling 9.20
bar=donor   line=cohort median 		12.92 16.8%
CETP Lipid Metabolism 0.38
bar=donor   line=cohort median 		0.40 44.3%
SIRT6 Sirtuin Family 3.84
bar=donor   line=cohort median 		3.67 58.3%
SIRT1 Sirtuin Family 3.09
bar=donor   line=cohort median 		3.48 30.3%
SIRT3 Sirtuin Family 1.25
bar=donor   line=cohort median 		1.10 69.2%
IGF1R Insulin/IGF-1 Signaling 4.13
bar=donor   line=cohort median 		4.33 47.9%
KLOTHO Anti-aging 0.12
bar=donor   line=cohort median 		0.06 80.1%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.25
bar=donor   line=cohort median 		0.07 93.0%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 67.6%
IRS2 Insulin/IGF-1 Signaling 20.43
bar=donor   line=cohort median 		35.28 19.4%
TP53 Tumor Suppression 2.59
bar=donor   line=cohort median 		3.83 12.7%
SHC1 Signal Transduction 8.69
bar=donor   line=cohort median 		8.77 46.4%
ACE Signal Transduction 0.70
bar=donor   line=cohort median 		0.39 86.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 11,925.5 89,545
2 MT-CO1 ENSG00000198804 protein_coding 8,422.5 170,191
3 MT-RNR2 ENSG00000210082 Mt_rRNA 6,956.8 142,123
4 MT-CO3 ENSG00000198938 protein_coding 6,776.3 69,618
5 MT-CO2 ENSG00000198712 protein_coding 6,174.0 55,339
6 MT-ND3 ENSG00000198840 protein_coding 5,550.7 25,167
7 MT-ND4 ENSG00000198886 protein_coding 4,554.6 82,245
8 MT-ND1 ENSG00000198888 protein_coding 4,410.3 55,250
9 EEF1A1P5 ENSG00000196205 processed_pseudogene 4,249.7 77,352
10 FTL ENSG00000087086 protein_coding 4,135.6 47,203

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,101.8
bar=donor   line=cohort median 		1,223.7 1,385.4 80.6%
2 S100A9 protein_coding 11,925.5
bar=donor   line=cohort median 		7,732.1 9,235.1 68.1%
3 IL1B protein_coding 7.6
bar=donor   line=cohort median 		4.9 6.1 64.5%
4 CXCL8 protein_coding 87.7
bar=donor   line=cohort median 		197.4 207.4 16.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 3.2
bar=donor   line=cohort median 		2.9 2.4 67.6%
6 FCGR3B protein_coding 90.2
bar=donor   line=cohort median 		108.9 129.3 28.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,685.7
bar=donor   line=cohort median 		581.4 706.2 94.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 76.9
bar=donor   line=cohort median 		51.6 56.4 72.3%
9 CD3E protein_coding 41.1
bar=donor   line=cohort median 		38.1 37.7 59.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 11.8
bar=donor   line=cohort median 		3.0 3.1 96.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 171.9
bar=donor   line=cohort median 		252.2 281.6 18.9%
12 GNLY protein_coding 30.0
bar=donor   line=cohort median 		58.9 70.7 8.0%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 994.2
bar=donor   line=cohort median 		585.0 582.1 71.2%
14 HBA1 protein_coding 3,490.7
bar=donor   line=cohort median 		1,960.4 1,960.7 68.1%
15 HBA2 protein_coding 1,950.9
bar=donor   line=cohort median 		1,080.5 1,083.5 69.7%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,422.5
bar=donor   line=cohort median 		6,740.9 6,938.4 73.8%
17 MT-CO2 protein_coding 6,174.0
bar=donor   line=cohort median 		5,693.7 5,810.8 57.8%
18 MT-ND1 protein_coding 4,410.3
bar=donor   line=cohort median 		3,876.8 3,718.2 69.7%
◂ Previous Donor Back to Donor List Next Donor ▸