GSM6881228

Dataset: gse221521 • Sample: DM group RNA145 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

13,690,136 Total counts Group median: 12,709,871 • 80.1%ile (↑ High)
26,211 Detected genes Group median: 2,638 • 40.7%ile (≈ Median)
4 Mitochondrial fraction (%) Group median: 6 • 11.7%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

57.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.27
bar=donor   line=cohort median 		0.17 75.9%
FOXO3 Insulin/IGF-1 Signaling 12.58
bar=donor   line=cohort median 		12.92 44.3%
CETP Lipid Metabolism 0.93
bar=donor   line=cohort median 		0.40 96.1%
SIRT6 Sirtuin Family 5.67
bar=donor   line=cohort median 		3.67 98.2%
SIRT1 Sirtuin Family 3.06
bar=donor   line=cohort median 		3.48 29.3%
SIRT3 Sirtuin Family 1.07
bar=donor   line=cohort median 		1.10 42.8%
IGF1R Insulin/IGF-1 Signaling 5.31
bar=donor   line=cohort median 		4.33 66.6%
KLOTHO Anti-aging 0.09
bar=donor   line=cohort median 		0.06 65.0%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.10
bar=donor   line=cohort median 		0.07 72.3%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 65.0%
IRS2 Insulin/IGF-1 Signaling 43.90
bar=donor   line=cohort median 		35.28 62.4%
TP53 Tumor Suppression 3.13
bar=donor   line=cohort median 		3.83 25.1%
SHC1 Signal Transduction 8.59
bar=donor   line=cohort median 		8.77 44.8%
ACE Signal Transduction 0.22
bar=donor   line=cohort median 		0.39 19.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 21,986.2 172,470
2 MT-RNR2 ENSG00000210082 Mt_rRNA 7,143.9 152,471
3 HBA1 ENSG00000206172 protein_coding 6,710.1 158,004
4 FTL ENSG00000087086 protein_coding 6,035.7 71,970
5 MT-CO1 ENSG00000198804 protein_coding 4,909.9 103,648
6 MT-CO3 ENSG00000198938 protein_coding 4,618.2 49,567
7 MT-CO2 ENSG00000198712 protein_coding 4,369.5 40,916
8 HBA2 ENSG00000188536 protein_coding 4,202.3 97,110
9 MT-RNR1 ENSG00000211459 Mt_rRNA 3,834.3 50,078
10 MT-ND3 ENSG00000198840 protein_coding 3,413.5 16,169

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,752.8
bar=donor   line=cohort median 		1,568.6 1,385.4 66.6%
2 S100A9 protein_coding 21,986.2
bar=donor   line=cohort median 		10,144.6 9,235.1 95.6%
3 IL1B protein_coding 6.7
bar=donor   line=cohort median 		6.9 6.1 57.8%
4 CXCL8 protein_coding 197.4
bar=donor   line=cohort median 		225.8 207.4 45.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 10.9
bar=donor   line=cohort median 		2.2 2.4 97.2%
6 FCGR3B protein_coding 279.2
bar=donor   line=cohort median 		157.0 129.3 92.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,064.5
bar=donor   line=cohort median 		802.6 706.2 75.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 46.4
bar=donor   line=cohort median 		56.8 56.4 32.4%
9 CD3E protein_coding 39.5
bar=donor   line=cohort median 		36.9 37.7 55.7%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.0
bar=donor   line=cohort median 		3.2 3.1 18.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 295.4
bar=donor   line=cohort median 		296.3 281.6 53.6%
12 GNLY protein_coding 209.5
bar=donor   line=cohort median 		77.5 70.7 97.7%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,064.8
bar=donor   line=cohort median 		509.6 582.1 72.8%
14 HBA1 protein_coding 6,710.1
bar=donor   line=cohort median 		1,931.5 1,960.7 87.3%
15 HBA2 protein_coding 4,202.3
bar=donor   line=cohort median 		1,068.0 1,083.5 88.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 4,909.9
bar=donor   line=cohort median 		7,011.1 6,938.4 11.7%
17 MT-CO2 protein_coding 4,369.5
bar=donor   line=cohort median 		5,968.9 5,810.8 14.8%
18 MT-ND1 protein_coding 1,967.6
bar=donor   line=cohort median 		3,670.4 3,718.2 7.0%
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