GSM6881229

Dataset: gse221521 • Sample: DR group RNA150 • Status: Diabetic retinopathy
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Quality Control Metrics

12,361,935 Total counts Group median: 12,498,211 • 40.2%ile (≈ Median)
28,809 Detected genes Group median: 27,368 • 96.1%ile (↑ High)
4 Mitochondrial fraction (%) Group median: 6 • 10.6%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

57.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.28
bar=donor   line=cohort median 		0.17 77.5%
FOXO3 Insulin/IGF-1 Signaling 13.04
bar=donor   line=cohort median 		12.92 51.0%
CETP Lipid Metabolism 0.55
bar=donor   line=cohort median 		0.40 76.9%
SIRT6 Sirtuin Family 3.38
bar=donor   line=cohort median 		3.67 33.4%
SIRT1 Sirtuin Family 3.43
bar=donor   line=cohort median 		3.48 44.8%
SIRT3 Sirtuin Family 1.00
bar=donor   line=cohort median 		1.10 31.9%
IGF1R Insulin/IGF-1 Signaling 5.88
bar=donor   line=cohort median 		4.33 75.9%
KLOTHO Anti-aging 0.09
bar=donor   line=cohort median 		0.06 63.0%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.10
bar=donor   line=cohort median 		0.07 67.1%
TERT Telomere Maintenance 0.06
bar=donor   line=cohort median 		0.01 94.0%
IRS2 Insulin/IGF-1 Signaling 25.18
bar=donor   line=cohort median 		35.28 28.8%
TP53 Tumor Suppression 3.83
bar=donor   line=cohort median 		3.83 49.5%
SHC1 Signal Transduction 9.58
bar=donor   line=cohort median 		8.77 76.9%
ACE Signal Transduction 0.33
bar=donor   line=cohort median 		0.39 41.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 12,312.5 87,214
2 MT-RNR2 ENSG00000210082 Mt_rRNA 5,182.5 99,878
3 MT-CO1 ENSG00000198804 protein_coding 4,512.1 86,011
4 MT-ATP6 ENSG00000198899 protein_coding 4,313.0 36,309
5 FTL ENSG00000087086 protein_coding 3,997.7 43,044
6 MT-CO2 ENSG00000198712 protein_coding 3,904.2 33,012
7 MT-CO3 ENSG00000198938 protein_coding 3,333.7 32,309
8 TMSB4XP8 ENSG00000187653 processed_pseudogene 2,960.1 4,940
9 MT-ND1 ENSG00000198888 protein_coding 2,613.0 30,881
10 MT-RNR1 ENSG00000211459 Mt_rRNA 2,608.2 30,759

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,903.6
bar=donor   line=cohort median 		1,223.7 1,385.4 73.3%
2 S100A9 protein_coding 12,312.5
bar=donor   line=cohort median 		7,732.1 9,235.1 71.8%
3 IL1B protein_coding 5.4
bar=donor   line=cohort median 		4.9 6.1 44.3%
4 CXCL8 protein_coding 87.2
bar=donor   line=cohort median 		197.4 207.4 16.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.9
bar=donor   line=cohort median 		2.9 2.4 41.7%
6 FCGR3B protein_coding 468.9
bar=donor   line=cohort median 		108.9 129.3 98.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 473.8
bar=donor   line=cohort median 		581.4 706.2 24.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 41.8
bar=donor   line=cohort median 		51.6 56.4 27.2%
9 CD3E protein_coding 34.0
bar=donor   line=cohort median 		38.1 37.7 39.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.4
bar=donor   line=cohort median 		3.0 3.1 60.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 246.0
bar=donor   line=cohort median 		252.2 281.6 38.1%
12 GNLY protein_coding 39.2
bar=donor   line=cohort median 		58.9 70.7 15.8%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 336.5
bar=donor   line=cohort median 		585.0 582.1 28.8%
14 HBA1 protein_coding 1,251.1
bar=donor   line=cohort median 		1,960.4 1,960.7 35.5%
15 HBA2 protein_coding 777.6
bar=donor   line=cohort median 		1,080.5 1,083.5 37.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 4,512.1
bar=donor   line=cohort median 		6,740.9 6,938.4 8.0%
17 MT-CO2 protein_coding 3,904.2
bar=donor   line=cohort median 		5,693.7 5,810.8 10.6%
18 MT-ND1 protein_coding 2,613.0
bar=donor   line=cohort median 		3,876.8 3,718.2 17.4%
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