GSM6881230

Dataset: gse221521 • Sample: DM group RNA151 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

13,787,629 Total counts Group median: 12,709,871 • 81.6%ile (↑ High)
26,054 Detected genes Group median: 2,638 • 35.5%ile (≈ Median)
4 Mitochondrial fraction (%) Group median: 6 • 13.2%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

36.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.12
bar=donor   line=cohort median 		0.17 37.1%
FOXO3 Insulin/IGF-1 Signaling 7.29
bar=donor   line=cohort median 		12.92 9.6%
CETP Lipid Metabolism 0.84
bar=donor   line=cohort median 		0.40 92.5%
SIRT6 Sirtuin Family 3.79
bar=donor   line=cohort median 		3.67 56.2%
SIRT1 Sirtuin Family 2.82
bar=donor   line=cohort median 		3.48 20.0%
SIRT3 Sirtuin Family 0.62
bar=donor   line=cohort median 		1.10 1.8%
IGF1R Insulin/IGF-1 Signaling 2.11
bar=donor   line=cohort median 		4.33 19.4%
KLOTHO Anti-aging 0.05
bar=donor   line=cohort median 		0.06 41.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.09
bar=donor   line=cohort median 		0.07 61.4%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 16.85
bar=donor   line=cohort median 		35.28 12.7%
TP53 Tumor Suppression 4.00
bar=donor   line=cohort median 		3.83 57.3%
SHC1 Signal Transduction 8.12
bar=donor   line=cohort median 		8.77 27.2%
ACE Signal Transduction 0.33
bar=donor   line=cohort median 		0.39 40.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 16,663.4 131,646
2 MT-RNR2 ENSG00000210082 Mt_rRNA 7,549.1 162,267
3 FTL ENSG00000087086 protein_coding 5,845.3 70,196
4 MT-CO1 ENSG00000198804 protein_coding 5,176.0 110,045
5 ISG15 ENSG00000187608 protein_coding 4,741.4 94,006
6 MT-RNR1 ENSG00000211459 Mt_rRNA 4,229.2 55,629
7 MT-CO2 ENSG00000198712 protein_coding 3,975.8 37,495
8 TMSB10 ENSG00000034510 protein_coding 3,729.6 23,706
9 MT-CO3 ENSG00000198938 protein_coding 3,590.4 38,810
10 TMSB4XP8 ENSG00000187653 processed_pseudogene 3,267.0 6,081

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,344.6
bar=donor   line=cohort median 		1,568.6 1,385.4 84.2%
2 S100A9 protein_coding 16,663.4
bar=donor   line=cohort median 		10,144.6 9,235.1 87.8%
3 IL1B protein_coding 16.8
bar=donor   line=cohort median 		6.9 6.1 92.5%
4 CXCL8 protein_coding 28.8
bar=donor   line=cohort median 		225.8 207.4 4.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.8
bar=donor   line=cohort median 		2.2 2.4 60.4%
6 FCGR3B protein_coding 209.9
bar=donor   line=cohort median 		157.0 129.3 79.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,568.7
bar=donor   line=cohort median 		802.6 706.2 92.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 25.9
bar=donor   line=cohort median 		56.8 56.4 3.9%
9 CD3E protein_coding 16.7
bar=donor   line=cohort median 		36.9 37.7 3.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.2
bar=donor   line=cohort median 		3.2 3.1 22.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 192.9
bar=donor   line=cohort median 		296.3 281.6 23.6%
12 GNLY protein_coding 55.9
bar=donor   line=cohort median 		77.5 70.7 32.9%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 51.0
bar=donor   line=cohort median 		509.6 582.1 0.8%
14 HBA1 protein_coding 299.2
bar=donor   line=cohort median 		1,931.5 1,960.7 2.3%
15 HBA2 protein_coding 178.2
bar=donor   line=cohort median 		1,068.0 1,083.5 3.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,176.0
bar=donor   line=cohort median 		7,011.1 6,938.4 14.8%
17 MT-CO2 protein_coding 3,975.8
bar=donor   line=cohort median 		5,968.9 5,810.8 11.1%
18 MT-ND1 protein_coding 2,913.0
bar=donor   line=cohort median 		3,670.4 3,718.2 22.5%
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