GSM6881231

Dataset: gse221521 • Sample: DM group RNA152 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

11,893,095 Total counts Group median: 12,709,871 • 23.6%ile (↓ Low)
28,005 Detected genes Group median: 2,638 • 88.9%ile (↑ High)
6 Mitochondrial fraction (%) Group median: 6 • 51.0%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

62.5Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.22
bar=donor   line=cohort median 		0.17 68.7%
FOXO3 Insulin/IGF-1 Signaling 10.87
bar=donor   line=cohort median 		12.92 29.3%
CETP Lipid Metabolism 0.46
bar=donor   line=cohort median 		0.40 62.4%
SIRT6 Sirtuin Family 5.10
bar=donor   line=cohort median 		3.67 94.0%
SIRT1 Sirtuin Family 3.43
bar=donor   line=cohort median 		3.48 45.3%
SIRT3 Sirtuin Family 1.25
bar=donor   line=cohort median 		1.10 67.1%
IGF1R Insulin/IGF-1 Signaling 4.80
bar=donor   line=cohort median 		4.33 57.8%
KLOTHO Anti-aging 0.10
bar=donor   line=cohort median 		0.06 72.8%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.10
bar=donor   line=cohort median 		0.07 71.8%
TERT Telomere Maintenance 0.07
bar=donor   line=cohort median 		0.01 96.6%
IRS2 Insulin/IGF-1 Signaling 27.64
bar=donor   line=cohort median 		35.28 35.5%
TP53 Tumor Suppression 4.72
bar=donor   line=cohort median 		3.83 72.3%
SHC1 Signal Transduction 9.35
bar=donor   line=cohort median 		8.77 69.2%
ACE Signal Transduction 0.36
bar=donor   line=cohort median 		0.39 45.9%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 11,973.0 81,593
2 MT-RNR2 ENSG00000210082 Mt_rRNA 8,231.4 152,622
3 MT-ATP6 ENSG00000198899 protein_coding 6,750.8 54,676
4 MT-CO1 ENSG00000198804 protein_coding 6,190.4 113,526
5 MT-CO2 ENSG00000198712 protein_coding 6,102.9 49,646
6 MT-RNR1 ENSG00000211459 Mt_rRNA 5,130.5 58,211
7 MT-ND3 ENSG00000198840 protein_coding 4,562.3 18,774
8 MT-CO3 ENSG00000198938 protein_coding 4,448.9 41,482
9 MT-ND4 ENSG00000198886 protein_coding 3,778.4 61,923
10 FTL ENSG00000087086 protein_coding 3,592.7 37,216

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,078.7
bar=donor   line=cohort median 		1,568.6 1,385.4 79.0%
2 S100A9 protein_coding 11,973.0
bar=donor   line=cohort median 		10,144.6 9,235.1 69.2%
3 IL1B protein_coding 10.6
bar=donor   line=cohort median 		6.9 6.1 80.6%
4 CXCL8 protein_coding 137.1
bar=donor   line=cohort median 		225.8 207.4 28.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.7
bar=donor   line=cohort median 		2.2 2.4 58.8%
6 FCGR3B protein_coding 134.2
bar=donor   line=cohort median 		157.0 129.3 52.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 484.4
bar=donor   line=cohort median 		802.6 706.2 26.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 76.3
bar=donor   line=cohort median 		56.8 56.4 71.2%
9 CD3E protein_coding 35.1
bar=donor   line=cohort median 		36.9 37.7 43.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 4.0
bar=donor   line=cohort median 		3.2 3.1 69.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 348.8
bar=donor   line=cohort median 		296.3 281.6 69.2%
12 GNLY protein_coding 107.4
bar=donor   line=cohort median 		77.5 70.7 74.9%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 153.5
bar=donor   line=cohort median 		509.6 582.1 9.1%
14 HBA1 protein_coding 681.3
bar=donor   line=cohort median 		1,931.5 1,960.7 15.8%
15 HBA2 protein_coding 433.4
bar=donor   line=cohort median 		1,068.0 1,083.5 18.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,190.4
bar=donor   line=cohort median 		7,011.1 6,938.4 33.9%
17 MT-CO2 protein_coding 6,102.9
bar=donor   line=cohort median 		5,968.9 5,810.8 56.2%
18 MT-ND1 protein_coding 3,467.6
bar=donor   line=cohort median 		3,670.4 3,718.2 39.6%
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