GSM6881233

Dataset: gse221521 • Sample: DR group RNA155 • Status: Diabetic retinopathy
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Quality Control Metrics

12,793,171 Total counts Group median: 12,498,211 • 56.7%ile (≈ Median)
25,570 Detected genes Group median: 27,368 • 21.0%ile (↓ Low)
6 Mitochondrial fraction (%) Group median: 6 • 44.3%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

39.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.27
bar=donor   line=cohort median 		0.17 75.4%
FOXO3 Insulin/IGF-1 Signaling 10.41
bar=donor   line=cohort median 		12.92 24.1%
CETP Lipid Metabolism 0.37
bar=donor   line=cohort median 		0.40 42.8%
SIRT6 Sirtuin Family 5.83
bar=donor   line=cohort median 		3.67 99.2%
SIRT1 Sirtuin Family 2.34
bar=donor   line=cohort median 		3.48 2.9%
SIRT3 Sirtuin Family 0.95
bar=donor   line=cohort median 		1.10 23.1%
IGF1R Insulin/IGF-1 Signaling 0.66
bar=donor   line=cohort median 		4.33 7.5%
KLOTHO Anti-aging 0.08
bar=donor   line=cohort median 		0.06 59.8%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.04
bar=donor   line=cohort median 		0.01 85.2%
IRS2 Insulin/IGF-1 Signaling 30.24
bar=donor   line=cohort median 		35.28 42.2%
TP53 Tumor Suppression 2.32
bar=donor   line=cohort median 		3.83 6.0%
SHC1 Signal Transduction 8.23
bar=donor   line=cohort median 		8.77 30.8%
ACE Signal Transduction 0.26
bar=donor   line=cohort median 		0.39 29.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 15,849.6 116,185
2 MT-RNR2 ENSG00000210082 Mt_rRNA 10,439.5 208,211
3 MT-CO2 ENSG00000198712 protein_coding 6,353.4 55,596
4 MT-RNR1 ENSG00000211459 Mt_rRNA 6,014.2 73,401
5 MT-CO1 ENSG00000198804 protein_coding 5,545.2 109,391
6 FTL ENSG00000087086 protein_coding 5,467.5 60,923
7 MT-CO3 ENSG00000198938 protein_coding 5,324.7 53,406
8 MT-ND3 ENSG00000198840 protein_coding 4,412.8 19,533
9 TMSB4XP8 ENSG00000187653 processed_pseudogene 3,880.0 6,701
10 JUNB ENSG00000171223 protein_coding 3,429.6 80,292

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,223.7
bar=donor   line=cohort median 		1,223.7 1,385.4 38.6%
2 S100A9 protein_coding 15,849.6
bar=donor   line=cohort median 		7,732.1 9,235.1 85.8%
3 IL1B protein_coding 6.1
bar=donor   line=cohort median 		4.9 6.1 50.5%
4 CXCL8 protein_coding 262.0
bar=donor   line=cohort median 		197.4 207.4 60.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.0
bar=donor   line=cohort median 		2.9 2.4 16.3%
6 FCGR3B protein_coding 294.0
bar=donor   line=cohort median 		108.9 129.3 93.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,573.3
bar=donor   line=cohort median 		581.4 706.2 92.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 112.4
bar=donor   line=cohort median 		51.6 56.4 90.9%
9 CD3E protein_coding 51.0
bar=donor   line=cohort median 		38.1 37.7 78.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 0.0
bar=donor   line=cohort median 		3.0 3.1 0.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 535.6
bar=donor   line=cohort median 		252.2 281.6 91.5%
12 GNLY protein_coding 114.9
bar=donor   line=cohort median 		58.9 70.7 79.0%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 585.0
bar=donor   line=cohort median 		585.0 582.1 51.0%
14 HBA1 protein_coding 1,717.4
bar=donor   line=cohort median 		1,960.4 1,960.7 44.3%
15 HBA2 protein_coding 1,214.3
bar=donor   line=cohort median 		1,080.5 1,083.5 57.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,545.2
bar=donor   line=cohort median 		6,740.9 6,938.4 22.5%
17 MT-CO2 protein_coding 6,353.4
bar=donor   line=cohort median 		5,693.7 5,810.8 63.0%
18 MT-ND1 protein_coding 3,367.9
bar=donor   line=cohort median 		3,876.8 3,718.2 36.0%
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