GSM6881234

Dataset: gse221521 • Sample: Control group RNA160 • Status: Healthy control
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Quality Control Metrics

3,531,785 Total counts Group median: 12,762,148 • 0.3%ile (↓ Low)
14,398 Detected genes Group median: 2,606 • 0.3%ile (↓ Low)
3 Mitochondrial fraction (%) Group median: 6 • 2.8%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

35.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.17 4.9%
FOXO3 Insulin/IGF-1 Signaling 1.82
bar=donor   line=cohort median 		12.92 1.3%
CETP Lipid Metabolism 2.14
bar=donor   line=cohort median 		0.40 99.7%
SIRT6 Sirtuin Family 5.08
bar=donor   line=cohort median 		3.67 93.0%
SIRT1 Sirtuin Family 0.00
bar=donor   line=cohort median 		3.48 0.3%
SIRT3 Sirtuin Family 1.99
bar=donor   line=cohort median 		1.10 99.7%
IGF1R Insulin/IGF-1 Signaling 0.94
bar=donor   line=cohort median 		4.33 9.6%
KLOTHO Anti-aging 0.00
bar=donor   line=cohort median 		0.06 5.2%
APOC3 Lipid Metabolism 0.76
bar=donor   line=cohort median 		0.00 99.7%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 20.17
bar=donor   line=cohort median 		35.28 18.4%
TP53 Tumor Suppression 0.90
bar=donor   line=cohort median 		3.83 0.3%
SHC1 Signal Transduction 5.38
bar=donor   line=cohort median 		8.77 1.3%
ACE Signal Transduction 0.54
bar=donor   line=cohort median 		0.39 74.9%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 38,450.1 77,812
2 TMSB10 ENSG00000034510 protein_coding 23,411.2 38,117
3 MT-TC ENSG00000210140 Mt_tRNA 17,593.5 4,101
4 RPL13AP5 ENSG00000236552 processed_pseudogene 16,257.1 35,139
5 RPL3P4 ENSG00000232573 processed_pseudogene 16,055.5 23,986
6 MT-TY ENSG00000210144 Mt_tRNA 12,252.4 2,856
7 RPS28P7 ENSG00000227097 processed_pseudogene 12,192.7 9,043
8 MT-RNR1 ENSG00000211459 Mt_rRNA 10,028.1 33,788
9 MT-TN ENSG00000210135 Mt_tRNA 7,900.9 2,037
10 MT-RNR2 ENSG00000210082 Mt_rRNA 7,602.9 41,862

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 6,189.8
bar=donor   line=cohort median 		1,535.8 1,385.4 99.7%
2 S100A9 protein_coding 38,450.1
bar=donor   line=cohort median 		10,851.3 9,235.1 99.7%
3 IL1B protein_coding 0.0
bar=donor   line=cohort median 		5.6 6.1 0.3%
4 CXCL8 protein_coding 71.2
bar=donor   line=cohort median 		220.4 207.4 11.7%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.0
bar=donor   line=cohort median 		1.7 2.4 0.5%
6 FCGR3B protein_coding 259.4
bar=donor   line=cohort median 		145.0 129.3 90.4%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 444.2
bar=donor   line=cohort median 		709.1 706.2 21.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 181.2
bar=donor   line=cohort median 		66.1 56.4 99.2%
9 CD3E protein_coding 4.2
bar=donor   line=cohort median 		37.6 37.7 0.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 1.4
bar=donor   line=cohort median 		3.1 3.1 8.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 417.1
bar=donor   line=cohort median 		302.3 281.6 79.0%
12 GNLY protein_coding 247.6
bar=donor   line=cohort median 		80.1 70.7 98.7%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 382.8
bar=donor   line=cohort median 		598.7 582.1 31.9%
14 HBA1 protein_coding 2,458.6
bar=donor   line=cohort median 		2,133.6 1,960.7 60.9%
15 HBA2 protein_coding 3,876.4
bar=donor   line=cohort median 		1,142.2 1,083.5 86.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 1,663.2
bar=donor   line=cohort median 		6,862.1 6,938.4 0.3%
17 MT-CO2 protein_coding 3,073.6
bar=donor   line=cohort median 		6,023.6 5,810.8 4.4%
18 MT-ND1 protein_coding 948.1
bar=donor   line=cohort median 		3,656.3 3,718.2 1.8%
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