GSM6881235

Dataset: gse221521 • Sample: DM group RNA165 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

11,384,491 Total counts Group median: 12,709,871 • 14.8%ile (↓ Low)
29,366 Detected genes Group median: 2,638 • 98.7%ile (↑ High)
5 Mitochondrial fraction (%) Group median: 6 • 17.4%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

65.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.23
bar=donor   line=cohort median 		0.17 70.7%
FOXO3 Insulin/IGF-1 Signaling 17.13
bar=donor   line=cohort median 		12.92 79.0%
CETP Lipid Metabolism 0.85
bar=donor   line=cohort median 		0.40 93.0%
SIRT6 Sirtuin Family 3.82
bar=donor   line=cohort median 		3.67 57.3%
SIRT1 Sirtuin Family 3.78
bar=donor   line=cohort median 		3.48 65.0%
SIRT3 Sirtuin Family 1.30
bar=donor   line=cohort median 		1.10 79.5%
IGF1R Insulin/IGF-1 Signaling 3.72
bar=donor   line=cohort median 		4.33 43.3%
KLOTHO Anti-aging 0.04
bar=donor   line=cohort median 		0.06 33.4%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.21
bar=donor   line=cohort median 		0.07 88.9%
TERT Telomere Maintenance 0.03
bar=donor   line=cohort median 		0.01 74.9%
IRS2 Insulin/IGF-1 Signaling 31.76
bar=donor   line=cohort median 		35.28 43.3%
TP53 Tumor Suppression 3.69
bar=donor   line=cohort median 		3.83 45.9%
SHC1 Signal Transduction 9.44
bar=donor   line=cohort median 		8.77 73.3%
ACE Signal Transduction 0.77
bar=donor   line=cohort median 		0.39 90.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 8,660.2 56,493
2 MT-CO1 ENSG00000198804 protein_coding 5,442.7 95,546
3 MT-ATP6 ENSG00000198899 protein_coding 5,116.6 39,668
4 MT-CO2 ENSG00000198712 protein_coding 4,985.8 38,824
5 MT-RNR2 ENSG00000210082 Mt_rRNA 4,932.3 87,540
6 G0S2 ENSG00000123689 protein_coding 3,753.4 37,432
7 FTL ENSG00000087086 protein_coding 3,653.3 36,226
8 MT-CO3 ENSG00000198938 protein_coding 3,638.9 32,479
9 HBA1 ENSG00000206172 protein_coding 3,501.1 68,556
10 MT-ND4 ENSG00000198886 protein_coding 3,204.4 50,270

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,474.8
bar=donor   line=cohort median 		1,568.6 1,385.4 53.1%
2 S100A9 protein_coding 8,660.2
bar=donor   line=cohort median 		10,144.6 9,235.1 46.4%
3 IL1B protein_coding 6.3
bar=donor   line=cohort median 		6.9 6.1 53.6%
4 CXCL8 protein_coding 629.7
bar=donor   line=cohort median 		225.8 207.4 93.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.2
bar=donor   line=cohort median 		2.2 2.4 47.4%
6 FCGR3B protein_coding 156.1
bar=donor   line=cohort median 		157.0 129.3 60.4%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 766.6
bar=donor   line=cohort median 		802.6 706.2 56.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 57.3
bar=donor   line=cohort median 		56.8 56.4 51.6%
9 CD3E protein_coding 39.6
bar=donor   line=cohort median 		36.9 37.7 56.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.4
bar=donor   line=cohort median 		3.2 3.1 57.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 285.8
bar=donor   line=cohort median 		296.3 281.6 52.1%
12 GNLY protein_coding 69.9
bar=donor   line=cohort median 		77.5 70.7 47.4%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 850.8
bar=donor   line=cohort median 		509.6 582.1 67.6%
14 HBA1 protein_coding 3,501.1
bar=donor   line=cohort median 		1,931.5 1,960.7 68.7%
15 HBA2 protein_coding 2,008.0
bar=donor   line=cohort median 		1,068.0 1,083.5 70.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,442.7
bar=donor   line=cohort median 		7,011.1 6,938.4 19.4%
17 MT-CO2 protein_coding 4,985.8
bar=donor   line=cohort median 		5,968.9 5,810.8 26.7%
18 MT-ND1 protein_coding 2,532.3
bar=donor   line=cohort median 		3,670.4 3,718.2 14.2%
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