GSM6881236

Dataset: gse221521 • Sample: Control group RNA167 • Status: Healthy control
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Quality Control Metrics

12,948,192 Total counts Group median: 12,762,148 • 62.4%ile (≈ Median)
27,942 Detected genes Group median: 2,606 • 88.3%ile (↑ High)
6 Mitochondrial fraction (%) Group median: 6 • 47.4%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

56.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.17 4.9%
FOXO3 Insulin/IGF-1 Signaling 17.76
bar=donor   line=cohort median 		12.92 82.6%
CETP Lipid Metabolism 0.31
bar=donor   line=cohort median 		0.40 29.8%
SIRT6 Sirtuin Family 3.88
bar=donor   line=cohort median 		3.67 60.9%
SIRT1 Sirtuin Family 4.28
bar=donor   line=cohort median 		3.48 76.4%
SIRT3 Sirtuin Family 1.26
bar=donor   line=cohort median 		1.10 70.2%
IGF1R Insulin/IGF-1 Signaling 5.16
bar=donor   line=cohort median 		4.33 65.0%
KLOTHO Anti-aging 0.01
bar=donor   line=cohort median 		0.06 13.7%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.29
bar=donor   line=cohort median 		0.07 96.6%
TERT Telomere Maintenance 0.01
bar=donor   line=cohort median 		0.01 42.8%
IRS2 Insulin/IGF-1 Signaling 59.54
bar=donor   line=cohort median 		35.28 81.1%
TP53 Tumor Suppression 3.19
bar=donor   line=cohort median 		3.83 26.7%
SHC1 Signal Transduction 10.44
bar=donor   line=cohort median 		8.77 91.5%
ACE Signal Transduction 0.47
bar=donor   line=cohort median 		0.39 63.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 11,855.4 87,959
2 MT-RNR2 ENSG00000210082 Mt_rRNA 9,520.2 192,177
3 MT-CO1 ENSG00000198804 protein_coding 5,791.7 115,637
4 MT-RNR1 ENSG00000211459 Mt_rRNA 5,600.0 69,175
5 MT-CO2 ENSG00000198712 protein_coding 5,377.5 47,626
6 MT-CO3 ENSG00000198938 protein_coding 5,211.9 52,908
7 FTL ENSG00000087086 protein_coding 4,262.9 48,077
8 MT-ND4 ENSG00000198886 protein_coding 3,784.1 67,518
9 MT-ND1 ENSG00000198888 protein_coding 3,718.2 46,026
10 G0S2 ENSG00000123689 protein_coding 3,495.8 39,651

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,770.1
bar=donor   line=cohort median 		1,535.8 1,385.4 67.1%
2 S100A9 protein_coding 11,855.4
bar=donor   line=cohort median 		10,851.3 9,235.1 66.6%
3 IL1B protein_coding 6.2
bar=donor   line=cohort median 		5.6 6.1 52.6%
4 CXCL8 protein_coding 823.4
bar=donor   line=cohort median 		220.4 207.4 97.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.9
bar=donor   line=cohort median 		1.7 2.4 42.2%
6 FCGR3B protein_coding 145.3
bar=donor   line=cohort median 		145.0 129.3 55.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 506.1
bar=donor   line=cohort median 		709.1 706.2 28.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 43.4
bar=donor   line=cohort median 		66.1 56.4 30.3%
9 CD3E protein_coding 31.2
bar=donor   line=cohort median 		37.6 37.7 29.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 5.4
bar=donor   line=cohort median 		3.1 3.1 85.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 96.4
bar=donor   line=cohort median 		302.3 281.6 2.8%
12 GNLY protein_coding 21.3
bar=donor   line=cohort median 		80.1 70.7 2.8%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 414.2
bar=donor   line=cohort median 		598.7 582.1 36.5%
14 HBA1 protein_coding 931.0
bar=donor   line=cohort median 		2,133.6 1,960.7 24.6%
15 HBA2 protein_coding 497.9
bar=donor   line=cohort median 		1,142.2 1,083.5 21.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,791.7
bar=donor   line=cohort median 		6,862.1 6,938.4 27.2%
17 MT-CO2 protein_coding 5,377.5
bar=donor   line=cohort median 		6,023.6 5,810.8 39.1%
18 MT-ND1 protein_coding 3,718.2
bar=donor   line=cohort median 		3,656.3 3,718.2 50.0%
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