GSM6881237

Dataset: gse221521 • Sample: DR group RNA174 • Status: Diabetic retinopathy
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Quality Control Metrics

12,461,996 Total counts Group median: 12,498,211 • 43.3%ile (≈ Median)
28,467 Detected genes Group median: 27,368 • 93.5%ile (↑ High)
6 Mitochondrial fraction (%) Group median: 6 • 60.9%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

54.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.17
bar=donor   line=cohort median 		0.17 52.1%
FOXO3 Insulin/IGF-1 Signaling 11.81
bar=donor   line=cohort median 		12.92 38.1%
CETP Lipid Metabolism 0.21
bar=donor   line=cohort median 		0.40 8.6%
SIRT6 Sirtuin Family 3.02
bar=donor   line=cohort median 		3.67 19.4%
SIRT1 Sirtuin Family 4.36
bar=donor   line=cohort median 		3.48 79.0%
SIRT3 Sirtuin Family 1.55
bar=donor   line=cohort median 		1.10 94.0%
IGF1R Insulin/IGF-1 Signaling 2.45
bar=donor   line=cohort median 		4.33 26.2%
KLOTHO Anti-aging 0.08
bar=donor   line=cohort median 		0.06 61.4%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.03
bar=donor   line=cohort median 		0.07 29.8%
TERT Telomere Maintenance 0.05
bar=donor   line=cohort median 		0.01 90.4%
IRS2 Insulin/IGF-1 Signaling 23.85
bar=donor   line=cohort median 		35.28 24.1%
TP53 Tumor Suppression 5.20
bar=donor   line=cohort median 		3.83 81.1%
SHC1 Signal Transduction 9.79
bar=donor   line=cohort median 		8.77 83.7%
ACE Signal Transduction 0.59
bar=donor   line=cohort median 		0.39 79.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 9,795.6 69,948
2 MT-RNR2 ENSG00000210082 Mt_rRNA 8,702.8 169,080
3 MT-CO1 ENSG00000198804 protein_coding 8,216.1 157,883
4 MT-CO3 ENSG00000198938 protein_coding 6,142.3 60,012
5 MT-CO2 ENSG00000198712 protein_coding 5,611.6 47,833
6 MT-RNR1 ENSG00000211459 Mt_rRNA 5,505.1 65,449
7 MT-ND4 ENSG00000198886 protein_coding 4,229.2 72,626
8 MT-ND1 ENSG00000198888 protein_coding 4,039.1 48,121
9 TMSB4XP8 ENSG00000187653 processed_pseudogene 3,828.5 6,441
10 MT-ND3 ENSG00000198840 protein_coding 3,655.7 15,763

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,238.5
bar=donor   line=cohort median 		1,223.7 1,385.4 40.2%
2 S100A9 protein_coding 9,795.6
bar=donor   line=cohort median 		7,732.1 9,235.1 54.7%
3 IL1B protein_coding 15.2
bar=donor   line=cohort median 		4.9 6.1 90.4%
4 CXCL8 protein_coding 361.7
bar=donor   line=cohort median 		197.4 207.4 76.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.0
bar=donor   line=cohort median 		2.9 2.4 44.3%
6 FCGR3B protein_coding 75.3
bar=donor   line=cohort median 		108.9 129.3 19.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,747.7
bar=donor   line=cohort median 		581.4 706.2 95.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 64.0
bar=donor   line=cohort median 		51.6 56.4 60.4%
9 CD3E protein_coding 39.3
bar=donor   line=cohort median 		38.1 37.7 55.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 5.9
bar=donor   line=cohort median 		3.0 3.1 88.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 173.0
bar=donor   line=cohort median 		252.2 281.6 19.4%
12 GNLY protein_coding 33.0
bar=donor   line=cohort median 		58.9 70.7 11.1%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 310.5
bar=donor   line=cohort median 		585.0 582.1 26.2%
14 HBA1 protein_coding 1,202.4
bar=donor   line=cohort median 		1,960.4 1,960.7 33.9%
15 HBA2 protein_coding 728.6
bar=donor   line=cohort median 		1,080.5 1,083.5 33.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,216.1
bar=donor   line=cohort median 		6,740.9 6,938.4 71.2%
17 MT-CO2 protein_coding 5,611.6
bar=donor   line=cohort median 		5,693.7 5,810.8 44.3%
18 MT-ND1 protein_coding 4,039.1
bar=donor   line=cohort median 		3,876.8 3,718.2 59.3%
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