GSM6881238

Dataset: gse221521 • Sample: DM group RNA179 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

12,175,615 Total counts Group median: 12,709,871 • 33.9%ile (≈ Median)
27,463 Detected genes Group median: 2,638 • 76.9%ile (↑ High)
6 Mitochondrial fraction (%) Group median: 6 • 54.1%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

40.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.07
bar=donor   line=cohort median 		0.17 20.0%
FOXO3 Insulin/IGF-1 Signaling 23.63
bar=donor   line=cohort median 		12.92 98.7%
CETP Lipid Metabolism 0.43
bar=donor   line=cohort median 		0.40 57.8%
SIRT6 Sirtuin Family 2.65
bar=donor   line=cohort median 		3.67 9.1%
SIRT1 Sirtuin Family 3.26
bar=donor   line=cohort median 		3.48 38.6%
SIRT3 Sirtuin Family 0.69
bar=donor   line=cohort median 		1.10 4.4%
IGF1R Insulin/IGF-1 Signaling 5.34
bar=donor   line=cohort median 		4.33 67.1%
KLOTHO Anti-aging 0.09
bar=donor   line=cohort median 		0.06 64.0%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.12
bar=donor   line=cohort median 		0.07 76.4%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 57.83
bar=donor   line=cohort median 		35.28 79.5%
TP53 Tumor Suppression 2.22
bar=donor   line=cohort median 		3.83 3.9%
SHC1 Signal Transduction 7.17
bar=donor   line=cohort median 		8.77 6.5%
ACE Signal Transduction 0.19
bar=donor   line=cohort median 		0.39 12.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 10,968.6 76,524
2 MT-RNR2 ENSG00000210082 Mt_rRNA 9,636.0 182,908
3 MT-CO1 ENSG00000198804 protein_coding 7,214.5 135,451
4 MT-CO3 ENSG00000198938 protein_coding 5,788.5 55,255
5 MT-CO2 ENSG00000198712 protein_coding 5,520.3 45,974
6 MT-RNR1 ENSG00000211459 Mt_rRNA 5,301.6 61,581
7 FTL ENSG00000087086 protein_coding 4,976.6 52,777
8 DUSP1 ENSG00000120129 protein_coding 4,636.2 113,631
9 MT-ND1 ENSG00000198888 protein_coding 4,016.3 46,749
10 MT-ND4 ENSG00000198886 protein_coding 3,937.5 66,064

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,621.2
bar=donor   line=cohort median 		1,568.6 1,385.4 57.8%
2 S100A9 protein_coding 10,968.6
bar=donor   line=cohort median 		10,144.6 9,235.1 62.4%
3 IL1B protein_coding 6.8
bar=donor   line=cohort median 		6.9 6.1 58.8%
4 CXCL8 protein_coding 837.1
bar=donor   line=cohort median 		225.8 207.4 98.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 6.2
bar=donor   line=cohort median 		2.2 2.4 84.2%
6 FCGR3B protein_coding 185.5
bar=donor   line=cohort median 		157.0 129.3 71.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,707.1
bar=donor   line=cohort median 		802.6 706.2 95.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 21.9
bar=donor   line=cohort median 		56.8 56.4 3.4%
9 CD3E protein_coding 18.3
bar=donor   line=cohort median 		36.9 37.7 5.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.6
bar=donor   line=cohort median 		3.2 3.1 36.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 105.0
bar=donor   line=cohort median 		296.3 281.6 3.4%
12 GNLY protein_coding 27.6
bar=donor   line=cohort median 		77.5 70.7 6.5%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 144.5
bar=donor   line=cohort median 		509.6 582.1 8.0%
14 HBA1 protein_coding 808.9
bar=donor   line=cohort median 		1,931.5 1,960.7 19.9%
15 HBA2 protein_coding 433.7
bar=donor   line=cohort median 		1,068.0 1,083.5 18.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,214.5
bar=donor   line=cohort median 		7,011.1 6,938.4 54.7%
17 MT-CO2 protein_coding 5,520.3
bar=donor   line=cohort median 		5,968.9 5,810.8 40.7%
18 MT-ND1 protein_coding 4,016.3
bar=donor   line=cohort median 		3,670.4 3,718.2 58.3%
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