GSM6881240

Dataset: gse221521 • Sample: DR group RNA18 • Status: Diabetic retinopathy
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Quality Control Metrics

12,158,383 Total counts Group median: 12,498,211 • 33.4%ile (≈ Median)
23,063 Detected genes Group median: 27,368 • 3.9%ile (↓ Low)
3 Mitochondrial fraction (%) Group median: 6 • 1.8%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

34.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.17 4.9%
FOXO3 Insulin/IGF-1 Signaling 20.20
bar=donor   line=cohort median 		12.92 95.6%
CETP Lipid Metabolism 0.37
bar=donor   line=cohort median 		0.40 42.2%
SIRT6 Sirtuin Family 1.12
bar=donor   line=cohort median 		3.67 1.3%
SIRT1 Sirtuin Family 7.60
bar=donor   line=cohort median 		3.48 99.2%
SIRT3 Sirtuin Family 0.64
bar=donor   line=cohort median 		1.10 2.9%
IGF1R Insulin/IGF-1 Signaling 2.17
bar=donor   line=cohort median 		4.33 20.5%
KLOTHO Anti-aging 0.00
bar=donor   line=cohort median 		0.06 5.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.02
bar=donor   line=cohort median 		0.07 24.1%
TERT Telomere Maintenance 0.07
bar=donor   line=cohort median 		0.01 96.1%
IRS2 Insulin/IGF-1 Signaling 22.72
bar=donor   line=cohort median 		35.28 21.5%
TP53 Tumor Suppression 4.10
bar=donor   line=cohort median 		3.83 59.3%
SHC1 Signal Transduction 4.45
bar=donor   line=cohort median 		8.77 0.3%
ACE Signal Transduction 0.00
bar=donor   line=cohort median 		0.39 0.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 10,514.4 199,300
2 S100A9 ENSG00000163220 protein_coding 6,156.5 42,891
3 MT-CO1 ENSG00000198804 protein_coding 5,964.1 111,817
4 TMSB4XP8 ENSG00000187653 processed_pseudogene 4,877.0 8,005
5 H3P6 ENSG00000235655 processed_pseudogene 3,062.2 15,302
6 EEF1A1P5 ENSG00000196205 processed_pseudogene 3,019.1 50,986
7 SRGN ENSG00000122862 protein_coding 2,328.7 57,164
8 RPS28P7 ENSG00000227097 processed_pseudogene 1,916.0 4,892
9 MT-CO3 ENSG00000198938 protein_coding 1,913.2 18,237
10 AC113935.1 ENSG00000226084 processed_pseudogene 1,766.5 11,920

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 841.0
bar=donor   line=cohort median 		1,223.7 1,385.4 15.8%
2 S100A9 protein_coding 6,156.5
bar=donor   line=cohort median 		7,732.1 9,235.1 23.1%
3 IL1B protein_coding 18.6
bar=donor   line=cohort median 		4.9 6.1 94.0%
4 CXCL8 protein_coding 802.4
bar=donor   line=cohort median 		197.4 207.4 96.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.4
bar=donor   line=cohort median 		2.9 2.4 4.9%
6 FCGR3B protein_coding 463.5
bar=donor   line=cohort median 		108.9 129.3 98.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,231.0
bar=donor   line=cohort median 		581.4 706.2 84.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 35.4
bar=donor   line=cohort median 		51.6 56.4 15.3%
9 CD3E protein_coding 21.3
bar=donor   line=cohort median 		38.1 37.7 7.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 21.8
bar=donor   line=cohort median 		3.0 3.1 98.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 34.7
bar=donor   line=cohort median 		252.2 281.6 0.3%
12 GNLY protein_coding 28.3
bar=donor   line=cohort median 		58.9 70.7 7.5%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 465.8
bar=donor   line=cohort median 		585.0 582.1 41.7%
14 HBA1 protein_coding 792.3
bar=donor   line=cohort median 		1,960.4 1,960.7 18.9%
15 HBA2 protein_coding 292.3
bar=donor   line=cohort median 		1,080.5 1,083.5 8.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,964.1
bar=donor   line=cohort median 		6,740.9 6,938.4 30.3%
17 MT-CO2 protein_coding 1,365.1
bar=donor   line=cohort median 		5,693.7 5,810.8 0.8%
18 MT-ND1 protein_coding 487.6
bar=donor   line=cohort median 		3,876.8 3,718.2 0.8%
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