GSM6881241

Dataset: gse221521 • Sample: DR group RNA185 • Status: Diabetic retinopathy
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Quality Control Metrics

12,770,785 Total counts Group median: 12,498,211 • 55.7%ile (≈ Median)
28,842 Detected genes Group median: 27,368 • 96.6%ile (↑ High)
6 Mitochondrial fraction (%) Group median: 6 • 36.0%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

52.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.35
bar=donor   line=cohort median 		0.17 90.4%
FOXO3 Insulin/IGF-1 Signaling 18.30
bar=donor   line=cohort median 		12.92 87.8%
CETP Lipid Metabolism 0.15
bar=donor   line=cohort median 		0.40 3.9%
SIRT6 Sirtuin Family 2.91
bar=donor   line=cohort median 		3.67 17.4%
SIRT1 Sirtuin Family 3.40
bar=donor   line=cohort median 		3.48 42.2%
SIRT3 Sirtuin Family 1.02
bar=donor   line=cohort median 		1.10 35.5%
IGF1R Insulin/IGF-1 Signaling 4.76
bar=donor   line=cohort median 		4.33 55.2%
KLOTHO Anti-aging 0.05
bar=donor   line=cohort median 		0.06 38.6%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.16
bar=donor   line=cohort median 		0.07 84.7%
TERT Telomere Maintenance 0.04
bar=donor   line=cohort median 		0.01 85.8%
IRS2 Insulin/IGF-1 Signaling 47.95
bar=donor   line=cohort median 		35.28 68.7%
TP53 Tumor Suppression 3.10
bar=donor   line=cohort median 		3.83 23.6%
SHC1 Signal Transduction 9.29
bar=donor   line=cohort median 		8.77 67.6%
ACE Signal Transduction 0.29
bar=donor   line=cohort median 		0.39 33.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-CO1 ENSG00000198804 protein_coding 8,820.5 173,699
2 S100A9 ENSG00000163220 protein_coding 6,629.6 48,513
3 MT-CO3 ENSG00000198938 protein_coding 5,910.9 59,182
4 MT-RNR2 ENSG00000210082 Mt_rRNA 5,518.0 109,861
5 MT-CO2 ENSG00000198712 protein_coding 5,090.4 44,466
6 MT-ND4 ENSG00000198886 protein_coding 3,975.0 69,952
7 FTL ENSG00000087086 protein_coding 3,807.8 42,355
8 TMSB4XP8 ENSG00000187653 processed_pseudogene 3,743.5 6,454
9 MT-ATP8 ENSG00000228253 protein_coding 3,362.1 8,888
10 MT-RNR1 ENSG00000211459 Mt_rRNA 3,201.2 39,001

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 920.5
bar=donor   line=cohort median 		1,223.7 1,385.4 19.4%
2 S100A9 protein_coding 6,629.6
bar=donor   line=cohort median 		7,732.1 9,235.1 28.2%
3 IL1B protein_coding 3.0
bar=donor   line=cohort median 		4.9 6.1 17.9%
4 CXCL8 protein_coding 429.5
bar=donor   line=cohort median 		197.4 207.4 84.7%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.0
bar=donor   line=cohort median 		2.9 2.4 45.9%
6 FCGR3B protein_coding 151.8
bar=donor   line=cohort median 		108.9 129.3 59.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 438.7
bar=donor   line=cohort median 		581.4 706.2 20.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 34.3
bar=donor   line=cohort median 		51.6 56.4 13.7%
9 CD3E protein_coding 53.6
bar=donor   line=cohort median 		38.1 37.7 82.6%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.7
bar=donor   line=cohort median 		3.0 3.1 39.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 562.3
bar=donor   line=cohort median 		252.2 281.6 93.5%
12 GNLY protein_coding 161.4
bar=donor   line=cohort median 		58.9 70.7 92.0%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 585.0
bar=donor   line=cohort median 		585.0 582.1 51.6%
14 HBA1 protein_coding 2,001.6
bar=donor   line=cohort median 		1,960.4 1,960.7 50.5%
15 HBA2 protein_coding 1,244.3
bar=donor   line=cohort median 		1,080.5 1,083.5 59.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,820.5
bar=donor   line=cohort median 		6,740.9 6,938.4 82.1%
17 MT-CO2 protein_coding 5,090.4
bar=donor   line=cohort median 		5,693.7 5,810.8 29.8%
18 MT-ND1 protein_coding 3,042.4
bar=donor   line=cohort median 		3,876.8 3,718.2 27.2%
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