GSM6881242

Dataset: gse221521 • Sample: DM group RNA2 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

12,508,227 Total counts Group median: 12,709,871 • 46.9%ile (≈ Median)
27,185 Detected genes Group median: 2,638 • 70.7%ile (≈ Median)
5 Mitochondrial fraction (%) Group median: 6 • 24.6%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

53.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.38
bar=donor   line=cohort median 		0.17 93.0%
FOXO3 Insulin/IGF-1 Signaling 15.46
bar=donor   line=cohort median 		12.92 68.7%
CETP Lipid Metabolism 0.34
bar=donor   line=cohort median 		0.40 36.0%
SIRT6 Sirtuin Family 3.81
bar=donor   line=cohort median 		3.67 56.7%
SIRT1 Sirtuin Family 3.10
bar=donor   line=cohort median 		3.48 30.8%
SIRT3 Sirtuin Family 1.37
bar=donor   line=cohort median 		1.10 86.3%
IGF1R Insulin/IGF-1 Signaling 3.91
bar=donor   line=cohort median 		4.33 45.9%
KLOTHO Anti-aging 0.15
bar=donor   line=cohort median 		0.06 86.8%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.05
bar=donor   line=cohort median 		0.07 40.2%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 23.98
bar=donor   line=cohort median 		35.28 25.1%
TP53 Tumor Suppression 3.32
bar=donor   line=cohort median 		3.83 31.4%
SHC1 Signal Transduction 8.58
bar=donor   line=cohort median 		8.77 43.8%
ACE Signal Transduction 0.85
bar=donor   line=cohort median 		0.39 92.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 12,161.8 87,166
2 HBA1 ENSG00000206172 protein_coding 12,017.1 258,538
3 MT-CO1 ENSG00000198804 protein_coding 7,905.6 152,480
4 HBA2 ENSG00000188536 protein_coding 7,673.4 162,015
5 MT-CO2 ENSG00000198712 protein_coding 5,874.6 50,261
6 TMSB4XP8 ENSG00000187653 processed_pseudogene 5,217.3 8,810
7 MT-CO3 ENSG00000198938 protein_coding 5,095.0 49,964
8 HBB ENSG00000244734 protein_coding 4,854.3 168,979
9 DEFA3 ENSG00000239839 protein_coding 4,729.4 29,223
10 MT-RNR2 ENSG00000210082 Mt_rRNA 4,657.0 90,813

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,625.1
bar=donor   line=cohort median 		1,568.6 1,385.4 89.9%
2 S100A9 protein_coding 12,161.8
bar=donor   line=cohort median 		10,144.6 9,235.1 70.2%
3 IL1B protein_coding 3.6
bar=donor   line=cohort median 		6.9 6.1 23.1%
4 CXCL8 protein_coding 119.2
bar=donor   line=cohort median 		225.8 207.4 24.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 168.7
bar=donor   line=cohort median 		2.2 2.4 99.7%
6 FCGR3B protein_coding 69.0
bar=donor   line=cohort median 		157.0 129.3 17.4%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 2,226.2
bar=donor   line=cohort median 		802.6 706.2 99.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 47.2
bar=donor   line=cohort median 		56.8 56.4 33.4%
9 CD3E protein_coding 31.1
bar=donor   line=cohort median 		36.9 37.7 28.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.3
bar=donor   line=cohort median 		3.2 3.1 55.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 178.5
bar=donor   line=cohort median 		296.3 281.6 21.0%
12 GNLY protein_coding 37.3
bar=donor   line=cohort median 		77.5 70.7 12.7%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 4,854.3
bar=donor   line=cohort median 		509.6 582.1 98.2%
14 HBA1 protein_coding 12,017.1
bar=donor   line=cohort median 		1,931.5 1,960.7 97.2%
15 HBA2 protein_coding 7,673.4
bar=donor   line=cohort median 		1,068.0 1,083.5 97.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,905.6
bar=donor   line=cohort median 		7,011.1 6,938.4 65.0%
17 MT-CO2 protein_coding 5,874.6
bar=donor   line=cohort median 		5,968.9 5,810.8 51.0%
18 MT-ND1 protein_coding 3,580.9
bar=donor   line=cohort median 		3,670.4 3,718.2 43.3%
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