GSM6881243

Dataset: gse221521 • Sample: DR group RNA201 • Status: Diabetic retinopathy
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Quality Control Metrics

15,371,441 Total counts Group median: 12,498,211 • 93.5%ile (↑ High)
26,614 Detected genes Group median: 27,368 • 55.4%ile (≈ Median)
8 Mitochondrial fraction (%) Group median: 6 • 82.6%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

47.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.24
bar=donor   line=cohort median 		0.17 71.8%
FOXO3 Insulin/IGF-1 Signaling 9.16
bar=donor   line=cohort median 		12.92 16.3%
CETP Lipid Metabolism 0.68
bar=donor   line=cohort median 		0.40 87.3%
SIRT6 Sirtuin Family 3.63
bar=donor   line=cohort median 		3.67 47.9%
SIRT1 Sirtuin Family 3.15
bar=donor   line=cohort median 		3.48 33.9%
SIRT3 Sirtuin Family 1.15
bar=donor   line=cohort median 		1.10 57.3%
IGF1R Insulin/IGF-1 Signaling 2.04
bar=donor   line=cohort median 		4.33 18.4%
KLOTHO Anti-aging 0.07
bar=donor   line=cohort median 		0.06 53.6%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.08
bar=donor   line=cohort median 		0.07 56.7%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 19.37
bar=donor   line=cohort median 		35.28 15.8%
TP53 Tumor Suppression 4.33
bar=donor   line=cohort median 		3.83 63.5%
SHC1 Signal Transduction 9.13
bar=donor   line=cohort median 		8.77 62.4%
ACE Signal Transduction 0.43
bar=donor   line=cohort median 		0.39 56.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 10,467.8 250,851
2 MT-CO1 ENSG00000198804 protein_coding 9,113.3 216,011
3 MT-CO2 ENSG00000198712 protein_coding 8,210.3 86,324
4 MT-CO3 ENSG00000198938 protein_coding 7,708.9 92,902
5 MT-RNR1 ENSG00000211459 Mt_rRNA 7,299.2 107,038
6 HBA1 ENSG00000206172 protein_coding 7,005.1 185,207
7 MT-ND1 ENSG00000198888 protein_coding 5,983.6 87,930
8 S100A9 ENSG00000163220 protein_coding 5,831.7 51,365
9 MT-ND4 ENSG00000198886 protein_coding 5,512.8 116,771
10 TMSB4XP8 ENSG00000187653 processed_pseudogene 5,109.0 10,602

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 830.2
bar=donor   line=cohort median 		1,223.7 1,385.4 15.3%
2 S100A9 protein_coding 5,831.7
bar=donor   line=cohort median 		7,732.1 9,235.1 18.9%
3 IL1B protein_coding 3.0
bar=donor   line=cohort median 		4.9 6.1 15.8%
4 CXCL8 protein_coding 25.0
bar=donor   line=cohort median 		197.4 207.4 3.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.2
bar=donor   line=cohort median 		2.9 2.4 49.0%
6 FCGR3B protein_coding 40.2
bar=donor   line=cohort median 		108.9 129.3 9.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 736.9
bar=donor   line=cohort median 		581.4 706.2 53.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 79.5
bar=donor   line=cohort median 		51.6 56.4 75.4%
9 CD3E protein_coding 50.5
bar=donor   line=cohort median 		38.1 37.7 76.9%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.2
bar=donor   line=cohort median 		3.0 3.1 51.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 638.7
bar=donor   line=cohort median 		252.2 281.6 95.6%
12 GNLY protein_coding 140.8
bar=donor   line=cohort median 		58.9 70.7 89.9%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,543.1
bar=donor   line=cohort median 		585.0 582.1 85.2%
14 HBA1 protein_coding 7,005.1
bar=donor   line=cohort median 		1,960.4 1,960.7 88.3%
15 HBA2 protein_coding 3,798.3
bar=donor   line=cohort median 		1,080.5 1,083.5 85.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 9,113.3
bar=donor   line=cohort median 		6,740.9 6,938.4 85.2%
17 MT-CO2 protein_coding 8,210.3
bar=donor   line=cohort median 		5,693.7 5,810.8 81.6%
18 MT-ND1 protein_coding 5,983.6
bar=donor   line=cohort median 		3,876.8 3,718.2 87.8%
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