GSM6881245

Dataset: gse221521 • Sample: DM group RNA205 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

12,078,020 Total counts Group median: 12,709,871 • 29.8%ile (≈ Median)
26,389 Detected genes Group median: 2,638 • 45.9%ile (≈ Median)
7 Mitochondrial fraction (%) Group median: 6 • 74.9%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

56.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.31
bar=donor   line=cohort median 		0.17 83.7%
FOXO3 Insulin/IGF-1 Signaling 12.54
bar=donor   line=cohort median 		12.92 43.8%
CETP Lipid Metabolism 0.29
bar=donor   line=cohort median 		0.40 26.7%
SIRT6 Sirtuin Family 4.98
bar=donor   line=cohort median 		3.67 90.9%
SIRT1 Sirtuin Family 3.49
bar=donor   line=cohort median 		3.48 52.6%
SIRT3 Sirtuin Family 1.29
bar=donor   line=cohort median 		1.10 78.0%
IGF1R Insulin/IGF-1 Signaling 5.26
bar=donor   line=cohort median 		4.33 66.1%
KLOTHO Anti-aging 0.15
bar=donor   line=cohort median 		0.06 88.9%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.22
bar=donor   line=cohort median 		0.07 89.9%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 32.89
bar=donor   line=cohort median 		35.28 45.9%
TP53 Tumor Suppression 2.91
bar=donor   line=cohort median 		3.83 18.4%
SHC1 Signal Transduction 8.21
bar=donor   line=cohort median 		8.77 29.3%
ACE Signal Transduction 0.50
bar=donor   line=cohort median 		0.39 70.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 15,270.7 105,684
2 MT-RNR2 ENSG00000210082 Mt_rRNA 11,534.0 217,181
3 MT-RNR1 ENSG00000211459 Mt_rRNA 8,102.9 93,365
4 MT-CO3 ENSG00000198938 protein_coding 7,370.9 69,796
5 MT-CO1 ENSG00000198804 protein_coding 6,889.9 128,320
6 MT-CO2 ENSG00000198712 protein_coding 6,523.6 53,894
7 FTL ENSG00000087086 protein_coding 5,946.1 62,553
8 MT-ND3 ENSG00000198840 protein_coding 5,795.9 24,221
9 MT-ND1 ENSG00000198888 protein_coding 4,753.7 54,889
10 TMSB4XP8 ENSG00000187653 processed_pseudogene 4,456.2 7,266

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,418.7
bar=donor   line=cohort median 		1,568.6 1,385.4 86.8%
2 S100A9 protein_coding 15,270.7
bar=donor   line=cohort median 		10,144.6 9,235.1 85.2%
3 IL1B protein_coding 3.9
bar=donor   line=cohort median 		6.9 6.1 26.2%
4 CXCL8 protein_coding 326.8
bar=donor   line=cohort median 		225.8 207.4 72.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.8
bar=donor   line=cohort median 		2.2 2.4 37.6%
6 FCGR3B protein_coding 332.0
bar=donor   line=cohort median 		157.0 129.3 95.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 755.5
bar=donor   line=cohort median 		802.6 706.2 56.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 78.8
bar=donor   line=cohort median 		56.8 56.4 74.9%
9 CD3E protein_coding 42.8
bar=donor   line=cohort median 		36.9 37.7 64.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 4.1
bar=donor   line=cohort median 		3.2 3.1 73.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 269.4
bar=donor   line=cohort median 		296.3 281.6 46.4%
12 GNLY protein_coding 73.5
bar=donor   line=cohort median 		77.5 70.7 51.6%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,624.7
bar=donor   line=cohort median 		509.6 582.1 86.8%
14 HBA1 protein_coding 3,938.7
bar=donor   line=cohort median 		1,931.5 1,960.7 73.8%
15 HBA2 protein_coding 2,579.5
bar=donor   line=cohort median 		1,068.0 1,083.5 79.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,889.9
bar=donor   line=cohort median 		7,011.1 6,938.4 47.9%
17 MT-CO2 protein_coding 6,523.6
bar=donor   line=cohort median 		5,968.9 5,810.8 65.0%
18 MT-ND1 protein_coding 4,753.7
bar=donor   line=cohort median 		3,670.4 3,718.2 76.4%
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