GSM6881246

Dataset: gse221521 • Sample: DM group RNA209 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

11,541,140 Total counts Group median: 12,709,871 • 16.8%ile (↓ Low)
26,318 Detected genes Group median: 2,638 • 43.8%ile (≈ Median)
4 Mitochondrial fraction (%) Group median: 6 • 7.5%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

55.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.39
bar=donor   line=cohort median 		0.17 94.0%
FOXO3 Insulin/IGF-1 Signaling 19.75
bar=donor   line=cohort median 		12.92 94.0%
CETP Lipid Metabolism 0.06
bar=donor   line=cohort median 		0.40 1.3%
SIRT6 Sirtuin Family 3.87
bar=donor   line=cohort median 		3.67 60.4%
SIRT1 Sirtuin Family 2.79
bar=donor   line=cohort median 		3.48 19.4%
SIRT3 Sirtuin Family 1.04
bar=donor   line=cohort median 		1.10 39.6%
IGF1R Insulin/IGF-1 Signaling 6.93
bar=donor   line=cohort median 		4.33 87.3%
KLOTHO Anti-aging 0.16
bar=donor   line=cohort median 		0.06 90.4%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.09
bar=donor   line=cohort median 		0.07 60.9%
TERT Telomere Maintenance 0.01
bar=donor   line=cohort median 		0.01 48.5%
IRS2 Insulin/IGF-1 Signaling 67.36
bar=donor   line=cohort median 		35.28 87.8%
TP53 Tumor Suppression 2.55
bar=donor   line=cohort median 		3.83 12.2%
SHC1 Signal Transduction 8.93
bar=donor   line=cohort median 		8.77 55.7%
ACE Signal Transduction 0.25
bar=donor   line=cohort median 		0.39 26.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 14,805.8 97,912
2 MT-RNR2 ENSG00000210082 Mt_rRNA 6,549.8 117,848
3 HBA1 ENSG00000206172 protein_coding 5,735.5 113,854
4 FTL ENSG00000087086 protein_coding 5,035.0 50,613
5 MT-CO1 ENSG00000198804 protein_coding 3,917.6 69,719
6 MT-CO3 ENSG00000198938 protein_coding 3,819.0 34,555
7 MT-CO2 ENSG00000198712 protein_coding 3,756.8 29,657
8 TMSB4XP8 ENSG00000187653 processed_pseudogene 3,569.2 5,561
9 HBA2 ENSG00000188536 protein_coding 3,511.6 68,412
10 MT-RNR1 ENSG00000211459 Mt_rRNA 3,361.0 37,005

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,802.3
bar=donor   line=cohort median 		1,568.6 1,385.4 68.7%
2 S100A9 protein_coding 14,805.8
bar=donor   line=cohort median 		10,144.6 9,235.1 82.1%
3 IL1B protein_coding 4.1
bar=donor   line=cohort median 		6.9 6.1 27.7%
4 CXCL8 protein_coding 533.5
bar=donor   line=cohort median 		225.8 207.4 90.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 18.4
bar=donor   line=cohort median 		2.2 2.4 99.2%
6 FCGR3B protein_coding 128.2
bar=donor   line=cohort median 		157.0 129.3 49.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 386.4
bar=donor   line=cohort median 		802.6 706.2 16.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 63.2
bar=donor   line=cohort median 		56.8 56.4 59.3%
9 CD3E protein_coding 37.1
bar=donor   line=cohort median 		36.9 37.7 47.9%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.1
bar=donor   line=cohort median 		3.2 3.1 49.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 233.1
bar=donor   line=cohort median 		296.3 281.6 34.5%
12 GNLY protein_coding 39.0
bar=donor   line=cohort median 		77.5 70.7 15.3%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,342.9
bar=donor   line=cohort median 		509.6 582.1 82.6%
14 HBA1 protein_coding 5,735.5
bar=donor   line=cohort median 		1,931.5 1,960.7 82.6%
15 HBA2 protein_coding 3,511.6
bar=donor   line=cohort median 		1,068.0 1,083.5 84.7%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 3,917.6
bar=donor   line=cohort median 		7,011.1 6,938.4 4.9%
17 MT-CO2 protein_coding 3,756.8
bar=donor   line=cohort median 		5,968.9 5,810.8 9.1%
18 MT-ND1 protein_coding 2,335.6
bar=donor   line=cohort median 		3,670.4 3,718.2 10.6%
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