GSM6881247

Dataset: gse221521 • Sample: DM group RNA213 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

12,746,126 Total counts Group median: 12,709,871 • 55.2%ile (≈ Median)
27,019 Detected genes Group median: 2,638 • 67.6%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 48.4%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

51.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.06
bar=donor   line=cohort median 		0.17 18.9%
FOXO3 Insulin/IGF-1 Signaling 10.65
bar=donor   line=cohort median 		12.92 26.2%
CETP Lipid Metabolism 0.61
bar=donor   line=cohort median 		0.40 83.2%
SIRT6 Sirtuin Family 4.78
bar=donor   line=cohort median 		3.67 87.8%
SIRT1 Sirtuin Family 3.04
bar=donor   line=cohort median 		3.48 28.8%
SIRT3 Sirtuin Family 1.25
bar=donor   line=cohort median 		1.10 68.1%
IGF1R Insulin/IGF-1 Signaling 1.77
bar=donor   line=cohort median 		4.33 15.8%
KLOTHO Anti-aging 0.00
bar=donor   line=cohort median 		0.06 5.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.09
bar=donor   line=cohort median 		0.07 65.0%
TERT Telomere Maintenance 0.05
bar=donor   line=cohort median 		0.01 88.9%
IRS2 Insulin/IGF-1 Signaling 49.74
bar=donor   line=cohort median 		35.28 72.3%
TP53 Tumor Suppression 2.49
bar=donor   line=cohort median 		3.83 9.1%
SHC1 Signal Transduction 9.47
bar=donor   line=cohort median 		8.77 73.8%
ACE Signal Transduction 0.70
bar=donor   line=cohort median 		0.39 86.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 11,024.9 80,521
2 MT-RNR2 ENSG00000210082 Mt_rRNA 9,194.7 182,709
3 MT-CO1 ENSG00000198804 protein_coding 7,215.6 141,820
4 MT-CO3 ENSG00000198938 protein_coding 6,345.4 63,409
5 MT-RNR1 ENSG00000211459 Mt_rRNA 5,581.3 67,868
6 MT-CO2 ENSG00000198712 protein_coding 5,576.1 48,614
7 FTL ENSG00000087086 protein_coding 5,197.3 57,700
8 MT-ND3 ENSG00000198840 protein_coding 3,982.4 17,563
9 TMSB4XP8 ENSG00000187653 processed_pseudogene 3,477.6 5,984
10 RPS28P7 ENSG00000227097 processed_pseudogene 3,430.4 9,182

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,697.8
bar=donor   line=cohort median 		1,568.6 1,385.4 62.4%
2 S100A9 protein_coding 11,024.9
bar=donor   line=cohort median 		10,144.6 9,235.1 63.5%
3 IL1B protein_coding 10.5
bar=donor   line=cohort median 		6.9 6.1 80.1%
4 CXCL8 protein_coding 320.9
bar=donor   line=cohort median 		225.8 207.4 71.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 6.6
bar=donor   line=cohort median 		2.2 2.4 85.2%
6 FCGR3B protein_coding 116.4
bar=donor   line=cohort median 		157.0 129.3 40.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 877.5
bar=donor   line=cohort median 		802.6 706.2 66.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 88.4
bar=donor   line=cohort median 		56.8 56.4 82.6%
9 CD3E protein_coding 48.8
bar=donor   line=cohort median 		36.9 37.7 74.9%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.0
bar=donor   line=cohort median 		3.2 3.1 47.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 373.3
bar=donor   line=cohort median 		296.3 281.6 73.3%
12 GNLY protein_coding 77.9
bar=donor   line=cohort median 		77.5 70.7 54.7%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 518.0
bar=donor   line=cohort median 		509.6 582.1 46.9%
14 HBA1 protein_coding 2,118.2
bar=donor   line=cohort median 		1,931.5 1,960.7 54.1%
15 HBA2 protein_coding 1,344.9
bar=donor   line=cohort median 		1,068.0 1,083.5 61.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,215.6
bar=donor   line=cohort median 		7,011.1 6,938.4 55.2%
17 MT-CO2 protein_coding 5,576.1
bar=donor   line=cohort median 		5,968.9 5,810.8 42.2%
18 MT-ND1 protein_coding 3,412.1
bar=donor   line=cohort median 		3,670.4 3,718.2 37.6%
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