GSM6881248

Dataset: gse221521 • Sample: Control group RNA218 • Status: Healthy control
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Quality Control Metrics

12,089,673 Total counts Group median: 12,762,148 • 30.3%ile (≈ Median)
24,178 Detected genes Group median: 2,606 • 6.0%ile (↓ Low)
7 Mitochondrial fraction (%) Group median: 6 • 75.4%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

40.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.09
bar=donor   line=cohort median 		0.17 27.7%
FOXO3 Insulin/IGF-1 Signaling 11.33
bar=donor   line=cohort median 		12.92 33.9%
CETP Lipid Metabolism 0.39
bar=donor   line=cohort median 		0.40 47.4%
SIRT6 Sirtuin Family 3.99
bar=donor   line=cohort median 		3.67 65.0%
SIRT1 Sirtuin Family 2.70
bar=donor   line=cohort median 		3.48 16.3%
SIRT3 Sirtuin Family 0.90
bar=donor   line=cohort median 		1.10 18.9%
IGF1R Insulin/IGF-1 Signaling 4.03
bar=donor   line=cohort median 		4.33 47.4%
KLOTHO Anti-aging 0.06
bar=donor   line=cohort median 		0.06 49.0%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.10
bar=donor   line=cohort median 		0.07 70.2%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 34.08
bar=donor   line=cohort median 		35.28 48.5%
TP53 Tumor Suppression 3.22
bar=donor   line=cohort median 		3.83 28.8%
SHC1 Signal Transduction 7.79
bar=donor   line=cohort median 		8.77 15.3%
ACE Signal Transduction 0.50
bar=donor   line=cohort median 		0.39 69.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 12,451.3 86,255
2 MT-RNR2 ENSG00000210082 Mt_rRNA 12,199.7 229,938
3 MT-CO2 ENSG00000198712 protein_coding 8,186.3 67,695
4 MT-RNR1 ENSG00000211459 Mt_rRNA 7,819.4 90,185
5 MT-CO1 ENSG00000198804 protein_coding 7,728.0 144,067
6 MT-CO3 ENSG00000198938 protein_coding 6,738.3 63,868
7 HBA1 ENSG00000206172 protein_coding 6,469.5 134,528
8 FTL ENSG00000087086 protein_coding 6,089.2 64,120
9 MT-ND1 ENSG00000198888 protein_coding 4,746.2 54,855
10 MT-ND3 ENSG00000198840 protein_coding 3,686.8 15,422

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,041.5
bar=donor   line=cohort median 		1,535.8 1,385.4 25.1%
2 S100A9 protein_coding 12,451.3
bar=donor   line=cohort median 		10,851.3 9,235.1 73.8%
3 IL1B protein_coding 2.6
bar=donor   line=cohort median 		5.6 6.1 13.7%
4 CXCL8 protein_coding 326.2
bar=donor   line=cohort median 		220.4 207.4 72.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.5
bar=donor   line=cohort median 		1.7 2.4 55.7%
6 FCGR3B protein_coding 187.3
bar=donor   line=cohort median 		145.0 129.3 71.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 750.8
bar=donor   line=cohort median 		709.1 706.2 55.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 47.8
bar=donor   line=cohort median 		66.1 56.4 35.0%
9 CD3E protein_coding 32.6
bar=donor   line=cohort median 		37.6 37.7 33.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.1
bar=donor   line=cohort median 		3.1 3.1 50.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 444.3
bar=donor   line=cohort median 		302.3 281.6 83.2%
12 GNLY protein_coding 121.4
bar=donor   line=cohort median 		80.1 70.7 83.7%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,552.8
bar=donor   line=cohort median 		598.7 582.1 85.8%
14 HBA1 protein_coding 6,469.5
bar=donor   line=cohort median 		2,133.6 1,960.7 86.3%
15 HBA2 protein_coding 2,844.6
bar=donor   line=cohort median 		1,142.2 1,083.5 80.1%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,728.0
bar=donor   line=cohort median 		6,862.1 6,938.4 61.9%
17 MT-CO2 protein_coding 8,186.3
bar=donor   line=cohort median 		6,023.6 5,810.8 81.1%
18 MT-ND1 protein_coding 4,746.2
bar=donor   line=cohort median 		3,656.3 3,718.2 75.9%
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