GSM6881249

Dataset: gse221521 • Sample: DM group RNA219 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

12,260,405 Total counts Group median: 12,709,871 • 36.0%ile (≈ Median)
26,093 Detected genes Group median: 2,638 • 37.0%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 40.7%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

53.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.41
bar=donor   line=cohort median 		0.17 95.1%
FOXO3 Insulin/IGF-1 Signaling 15.69
bar=donor   line=cohort median 		12.92 71.2%
CETP Lipid Metabolism 0.17
bar=donor   line=cohort median 		0.40 5.4%
SIRT6 Sirtuin Family 4.21
bar=donor   line=cohort median 		3.67 74.9%
SIRT1 Sirtuin Family 2.56
bar=donor   line=cohort median 		3.48 10.6%
SIRT3 Sirtuin Family 1.40
bar=donor   line=cohort median 		1.10 87.3%
IGF1R Insulin/IGF-1 Signaling 6.59
bar=donor   line=cohort median 		4.33 83.2%
KLOTHO Anti-aging 0.01
bar=donor   line=cohort median 		0.06 15.8%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.38
bar=donor   line=cohort median 		0.07 97.7%
TERT Telomere Maintenance 0.03
bar=donor   line=cohort median 		0.01 70.7%
IRS2 Insulin/IGF-1 Signaling 74.31
bar=donor   line=cohort median 		35.28 91.5%
TP53 Tumor Suppression 2.49
bar=donor   line=cohort median 		3.83 9.6%
SHC1 Signal Transduction 7.57
bar=donor   line=cohort median 		8.77 11.7%
ACE Signal Transduction 0.24
bar=donor   line=cohort median 		0.39 22.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 17,041.2 119,718
2 MT-RNR2 ENSG00000210082 Mt_rRNA 10,253.3 195,981
3 FTL ENSG00000087086 protein_coding 6,355.1 67,865
4 HBA1 ENSG00000206172 protein_coding 6,278.8 132,407
5 MT-RNR1 ENSG00000211459 Mt_rRNA 5,843.9 68,353
6 MT-CO2 ENSG00000198712 protein_coding 5,810.8 48,730
7 MT-CO3 ENSG00000198938 protein_coding 5,507.2 52,936
8 MT-CO1 ENSG00000198804 protein_coding 5,336.3 100,886
9 MT-ND1 ENSG00000198888 protein_coding 3,809.4 44,650
10 DUSP1 ENSG00000120129 protein_coding 3,612.3 89,152

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,551.5
bar=donor   line=cohort median 		1,568.6 1,385.4 88.3%
2 S100A9 protein_coding 17,041.2
bar=donor   line=cohort median 		10,144.6 9,235.1 89.9%
3 IL1B protein_coding 3.4
bar=donor   line=cohort median 		6.9 6.1 21.5%
4 CXCL8 protein_coding 387.7
bar=donor   line=cohort median 		225.8 207.4 79.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.7
bar=donor   line=cohort median 		2.2 2.4 34.5%
6 FCGR3B protein_coding 119.6
bar=donor   line=cohort median 		157.0 129.3 43.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 814.2
bar=donor   line=cohort median 		802.6 706.2 61.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 55.3
bar=donor   line=cohort median 		56.8 56.4 47.9%
9 CD3E protein_coding 42.4
bar=donor   line=cohort median 		36.9 37.7 63.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.3
bar=donor   line=cohort median 		3.2 3.1 27.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 333.1
bar=donor   line=cohort median 		296.3 281.6 65.0%
12 GNLY protein_coding 95.4
bar=donor   line=cohort median 		77.5 70.7 66.1%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,253.7
bar=donor   line=cohort median 		509.6 582.1 79.5%
14 HBA1 protein_coding 6,278.8
bar=donor   line=cohort median 		1,931.5 1,960.7 85.2%
15 HBA2 protein_coding 3,291.8
bar=donor   line=cohort median 		1,068.0 1,083.5 83.7%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,336.3
bar=donor   line=cohort median 		7,011.1 6,938.4 18.9%
17 MT-CO2 protein_coding 5,810.8
bar=donor   line=cohort median 		5,968.9 5,810.8 50.0%
18 MT-ND1 protein_coding 3,809.4
bar=donor   line=cohort median 		3,670.4 3,718.2 52.6%
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