GSM6881250

Dataset: gse221521 • Sample: Control group RNA220 • Status: Healthy control
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Quality Control Metrics

12,824,387 Total counts Group median: 12,762,148 • 57.8%ile (≈ Median)
27,181 Detected genes Group median: 2,606 • 70.2%ile (≈ Median)
8 Mitochondrial fraction (%) Group median: 6 • 78.5%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

51.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.08
bar=donor   line=cohort median 		0.17 24.1%
FOXO3 Insulin/IGF-1 Signaling 14.79
bar=donor   line=cohort median 		12.92 63.0%
CETP Lipid Metabolism 0.53
bar=donor   line=cohort median 		0.40 73.8%
SIRT6 Sirtuin Family 4.30
bar=donor   line=cohort median 		3.67 78.5%
SIRT1 Sirtuin Family 2.69
bar=donor   line=cohort median 		3.48 14.3%
SIRT3 Sirtuin Family 1.47
bar=donor   line=cohort median 		1.10 93.0%
IGF1R Insulin/IGF-1 Signaling 6.66
bar=donor   line=cohort median 		4.33 84.7%
KLOTHO Anti-aging 0.08
bar=donor   line=cohort median 		0.06 59.3%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.05
bar=donor   line=cohort median 		0.07 38.1%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 65.49
bar=donor   line=cohort median 		35.28 86.3%
TP53 Tumor Suppression 2.74
bar=donor   line=cohort median 		3.83 16.3%
SHC1 Signal Transduction 8.15
bar=donor   line=cohort median 		8.77 27.7%
ACE Signal Transduction 0.39
bar=donor   line=cohort median 		0.39 50.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 14,467.8 289,257
2 MT-RNR1 ENSG00000211459 Mt_rRNA 11,353.6 138,905
3 HBA1 ENSG00000206172 protein_coding 9,382.5 206,958
4 S100A9 ENSG00000163220 protein_coding 8,246.9 60,601
5 MT-CO2 ENSG00000198712 protein_coding 6,350.7 55,708
6 MT-CO3 ENSG00000198938 protein_coding 6,008.8 60,414
7 MT-CO1 ENSG00000198804 protein_coding 5,904.6 116,765
8 HBA2 ENSG00000188536 protein_coding 5,788.5 125,307
9 MT-ND1 ENSG00000198888 protein_coding 5,203.1 63,791
10 FTL ENSG00000087086 protein_coding 4,697.3 52,469

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,076.9
bar=donor   line=cohort median 		1,535.8 1,385.4 28.8%
2 S100A9 protein_coding 8,246.9
bar=donor   line=cohort median 		10,851.3 9,235.1 42.2%
3 IL1B protein_coding 1.6
bar=donor   line=cohort median 		5.6 6.1 7.5%
4 CXCL8 protein_coding 594.3
bar=donor   line=cohort median 		220.4 207.4 92.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.7
bar=donor   line=cohort median 		1.7 2.4 33.9%
6 FCGR3B protein_coding 81.0
bar=donor   line=cohort median 		145.0 129.3 24.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 280.7
bar=donor   line=cohort median 		709.1 706.2 9.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 88.7
bar=donor   line=cohort median 		66.1 56.4 83.2%
9 CD3E protein_coding 47.5
bar=donor   line=cohort median 		37.6 37.7 73.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.5
bar=donor   line=cohort median 		3.1 3.1 33.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 472.4
bar=donor   line=cohort median 		302.3 281.6 86.3%
12 GNLY protein_coding 83.7
bar=donor   line=cohort median 		80.1 70.7 59.8%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,836.3
bar=donor   line=cohort median 		598.7 582.1 90.4%
14 HBA1 protein_coding 9,382.5
bar=donor   line=cohort median 		2,133.6 1,960.7 92.0%
15 HBA2 protein_coding 5,788.5
bar=donor   line=cohort median 		1,142.2 1,083.5 95.1%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,904.6
bar=donor   line=cohort median 		6,862.1 6,938.4 29.3%
17 MT-CO2 protein_coding 6,350.7
bar=donor   line=cohort median 		6,023.6 5,810.8 62.4%
18 MT-ND1 protein_coding 5,203.1
bar=donor   line=cohort median 		3,656.3 3,718.2 81.6%
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