GSM6881252

Dataset: gse221521 • Sample: Control group RNA224 • Status: Healthy control
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Quality Control Metrics

14,475,926 Total counts Group median: 12,762,148 • 87.8%ile (↑ High)
26,398 Detected genes Group median: 2,606 • 46.9%ile (≈ Median)
9 Mitochondrial fraction (%) Group median: 6 • 86.8%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

51.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.68
bar=donor   line=cohort median 		0.17 99.7%
FOXO3 Insulin/IGF-1 Signaling 4.75
bar=donor   line=cohort median 		12.92 3.9%
CETP Lipid Metabolism 0.44
bar=donor   line=cohort median 		0.40 59.8%
SIRT6 Sirtuin Family 5.07
bar=donor   line=cohort median 		3.67 92.5%
SIRT1 Sirtuin Family 2.58
bar=donor   line=cohort median 		3.48 11.7%
SIRT3 Sirtuin Family 1.28
bar=donor   line=cohort median 		1.10 74.9%
IGF1R Insulin/IGF-1 Signaling 1.55
bar=donor   line=cohort median 		4.33 12.7%
KLOTHO Anti-aging 0.09
bar=donor   line=cohort median 		0.06 68.1%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 1.64
bar=donor   line=cohort median 		0.07 99.7%
TERT Telomere Maintenance 0.07
bar=donor   line=cohort median 		0.01 97.2%
IRS2 Insulin/IGF-1 Signaling 7.44
bar=donor   line=cohort median 		35.28 3.4%
TP53 Tumor Suppression 3.39
bar=donor   line=cohort median 		3.83 33.4%
SHC1 Signal Transduction 8.75
bar=donor   line=cohort median 		8.77 48.5%
ACE Signal Transduction 0.25
bar=donor   line=cohort median 		0.39 25.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 HBA1 ENSG00000206172 protein_coding 15,406.1 383,591
2 MT-RNR2 ENSG00000210082 Mt_rRNA 14,301.6 322,757
3 MT-CO2 ENSG00000198712 protein_coding 9,619.0 95,243
4 MT-RNR1 ENSG00000211459 Mt_rRNA 9,191.1 126,930
5 HBA2 ENSG00000188536 protein_coding 8,819.3 215,502
6 MT-CO1 ENSG00000198804 protein_coding 8,792.7 196,270
7 MT-CO3 ENSG00000198938 protein_coding 8,342.1 94,676
8 MT-ND3 ENSG00000198840 protein_coding 6,483.8 32,475
9 MT-ND1 ENSG00000198888 protein_coding 5,480.0 75,838
10 RPS28P7 ENSG00000227097 processed_pseudogene 5,031.7 15,296

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 515.5
bar=donor   line=cohort median 		1,535.8 1,385.4 7.5%
2 S100A9 protein_coding 3,230.9
bar=donor   line=cohort median 		10,851.3 9,235.1 8.5%
3 IL1B protein_coding 0.7
bar=donor   line=cohort median 		5.6 6.1 3.4%
4 CXCL8 protein_coding 31.0
bar=donor   line=cohort median 		220.4 207.4 6.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.1
bar=donor   line=cohort median 		1.7 2.4 21.0%
6 FCGR3B protein_coding 28.1
bar=donor   line=cohort median 		145.0 129.3 7.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 859.3
bar=donor   line=cohort median 		709.1 706.2 63.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 126.5
bar=donor   line=cohort median 		66.1 56.4 94.6%
9 CD3E protein_coding 83.0
bar=donor   line=cohort median 		37.6 37.7 96.6%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 9.5
bar=donor   line=cohort median 		3.1 3.1 95.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 664.0
bar=donor   line=cohort median 		302.3 281.6 96.1%
12 GNLY protein_coding 114.7
bar=donor   line=cohort median 		80.1 70.7 78.5%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 3,205.4
bar=donor   line=cohort median 		598.7 582.1 96.1%
14 HBA1 protein_coding 15,406.1
bar=donor   line=cohort median 		2,133.6 1,960.7 97.7%
15 HBA2 protein_coding 8,819.3
bar=donor   line=cohort median 		1,142.2 1,083.5 98.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,792.7
bar=donor   line=cohort median 		6,862.1 6,938.4 81.1%
17 MT-CO2 protein_coding 9,619.0
bar=donor   line=cohort median 		6,023.6 5,810.8 90.9%
18 MT-ND1 protein_coding 5,480.0
bar=donor   line=cohort median 		3,656.3 3,718.2 84.2%
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