GSM6881253

Dataset: gse221521 • Sample: DR group RNA23 • Status: Diabetic retinopathy
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Quality Control Metrics

12,515,443 Total counts Group median: 12,498,211 • 47.9%ile (≈ Median)
27,409 Detected genes Group median: 27,368 • 76.4%ile (↑ High)
7 Mitochondrial fraction (%) Group median: 6 • 77.5%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

43.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.06
bar=donor   line=cohort median 		0.17 19.4%
FOXO3 Insulin/IGF-1 Signaling 17.12
bar=donor   line=cohort median 		12.92 78.5%
CETP Lipid Metabolism 0.17
bar=donor   line=cohort median 		0.40 4.9%
SIRT6 Sirtuin Family 2.53
bar=donor   line=cohort median 		3.67 8.0%
SIRT1 Sirtuin Family 6.36
bar=donor   line=cohort median 		3.48 97.2%
SIRT3 Sirtuin Family 0.87
bar=donor   line=cohort median 		1.10 13.7%
IGF1R Insulin/IGF-1 Signaling 5.69
bar=donor   line=cohort median 		4.33 73.8%
KLOTHO Anti-aging 0.19
bar=donor   line=cohort median 		0.06 94.0%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.03
bar=donor   line=cohort median 		0.07 29.3%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 35.74
bar=donor   line=cohort median 		35.28 51.6%
TP53 Tumor Suppression 4.94
bar=donor   line=cohort median 		3.83 78.0%
SHC1 Signal Transduction 8.08
bar=donor   line=cohort median 		8.77 25.7%
ACE Signal Transduction 0.12
bar=donor   line=cohort median 		0.39 3.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 9,504.5 185,447
2 MT-CO1 ENSG00000198804 protein_coding 9,377.9 180,982
3 MT-ATP6 ENSG00000198899 protein_coding 8,111.3 69,133
4 TMSB4XP8 ENSG00000187653 processed_pseudogene 7,174.0 12,121
5 MT-CO2 ENSG00000198712 protein_coding 6,245.2 53,462
6 MT-ND4 ENSG00000198886 protein_coding 5,393.6 93,019
7 MT-ND1 ENSG00000198888 protein_coding 4,605.8 55,107
8 MT-CO3 ENSG00000198938 protein_coding 4,601.7 45,152
9 MT-ATP8 ENSG00000228253 protein_coding 4,427.8 11,471
10 MT-RNR1 ENSG00000211459 Mt_rRNA 4,274.9 51,041

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 697.4
bar=donor   line=cohort median 		1,223.7 1,385.4 11.1%
2 S100A9 protein_coding 2,822.8
bar=donor   line=cohort median 		7,732.1 9,235.1 6.5%
3 IL1B protein_coding 2.5
bar=donor   line=cohort median 		4.9 6.1 12.7%
4 CXCL8 protein_coding 174.3
bar=donor   line=cohort median 		197.4 207.4 38.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.7
bar=donor   line=cohort median 		2.9 2.4 36.5%
6 FCGR3B protein_coding 152.6
bar=donor   line=cohort median 		108.9 129.3 59.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 796.9
bar=donor   line=cohort median 		581.4 706.2 59.3%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 44.7
bar=donor   line=cohort median 		51.6 56.4 31.3%
9 CD3E protein_coding 38.6
bar=donor   line=cohort median 		38.1 37.7 53.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 8.3
bar=donor   line=cohort median 		3.0 3.1 93.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 247.7
bar=donor   line=cohort median 		252.2 281.6 39.1%
12 GNLY protein_coding 90.3
bar=donor   line=cohort median 		58.9 70.7 64.0%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 321.0
bar=donor   line=cohort median 		585.0 582.1 28.2%
14 HBA1 protein_coding 2,319.3
bar=donor   line=cohort median 		1,960.4 1,960.7 57.3%
15 HBA2 protein_coding 886.7
bar=donor   line=cohort median 		1,080.5 1,083.5 41.7%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 9,377.9
bar=donor   line=cohort median 		6,740.9 6,938.4 87.8%
17 MT-CO2 protein_coding 6,245.2
bar=donor   line=cohort median 		5,693.7 5,810.8 60.4%
18 MT-ND1 protein_coding 4,605.8
bar=donor   line=cohort median 		3,876.8 3,718.2 74.4%
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