GSM6881254

Dataset: gse221521 • Sample: Control group RNA242 • Status: Healthy control
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Quality Control Metrics

14,463,147 Total counts Group median: 12,762,148 • 87.3%ile (↑ High)
26,455 Detected genes Group median: 2,606 • 49.0%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 38.1%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

43.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.22
bar=donor   line=cohort median 		0.17 66.6%
FOXO3 Insulin/IGF-1 Signaling 6.57
bar=donor   line=cohort median 		12.92 6.5%
CETP Lipid Metabolism 0.31
bar=donor   line=cohort median 		0.40 30.3%
SIRT6 Sirtuin Family 5.05
bar=donor   line=cohort median 		3.67 92.0%
SIRT1 Sirtuin Family 3.42
bar=donor   line=cohort median 		3.48 43.3%
SIRT3 Sirtuin Family 1.40
bar=donor   line=cohort median 		1.10 86.8%
IGF1R Insulin/IGF-1 Signaling 0.56
bar=donor   line=cohort median 		4.33 4.9%
KLOTHO Anti-aging 0.04
bar=donor   line=cohort median 		0.06 35.0%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.04
bar=donor   line=cohort median 		0.07 35.5%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 51.6%
IRS2 Insulin/IGF-1 Signaling 9.23
bar=donor   line=cohort median 		35.28 7.0%
TP53 Tumor Suppression 4.08
bar=donor   line=cohort median 		3.83 58.8%
SHC1 Signal Transduction 8.47
bar=donor   line=cohort median 		8.77 38.6%
ACE Signal Transduction 0.36
bar=donor   line=cohort median 		0.39 45.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 21,326.0 176,737
2 MT-RNR2 ENSG00000210082 Mt_rRNA 8,435.4 190,201
3 MT-CO1 ENSG00000198804 protein_coding 6,337.5 141,341
4 MT-CO2 ENSG00000198712 protein_coding 6,196.3 61,299
5 MT-CO3 ENSG00000198938 protein_coding 6,148.8 69,722
6 FTL ENSG00000087086 protein_coding 6,079.7 76,589
7 MT-ND3 ENSG00000198840 protein_coding 4,614.3 23,091
8 MT-RNR1 ENSG00000211459 Mt_rRNA 4,445.8 61,343
9 RPS28P7 ENSG00000227097 processed_pseudogene 4,310.8 13,093
10 S100A8 ENSG00000143546 protein_coding 3,789.6 68,237

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 3,789.6
bar=donor   line=cohort median 		1,535.8 1,385.4 98.2%
2 S100A9 protein_coding 21,326.0
bar=donor   line=cohort median 		10,851.3 9,235.1 94.6%
3 IL1B protein_coding 33.0
bar=donor   line=cohort median 		5.6 6.1 99.2%
4 CXCL8 protein_coding 74.0
bar=donor   line=cohort median 		220.4 207.4 12.7%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.0
bar=donor   line=cohort median 		1.7 2.4 17.4%
6 FCGR3B protein_coding 194.2
bar=donor   line=cohort median 		145.0 129.3 74.4%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 809.8
bar=donor   line=cohort median 		709.1 706.2 60.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 110.4
bar=donor   line=cohort median 		66.1 56.4 89.9%
9 CD3E protein_coding 52.7
bar=donor   line=cohort median 		37.6 37.7 81.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 4.8
bar=donor   line=cohort median 		3.1 3.1 80.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 306.8
bar=donor   line=cohort median 		302.3 281.6 57.3%
12 GNLY protein_coding 76.2
bar=donor   line=cohort median 		80.1 70.7 52.6%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 562.3
bar=donor   line=cohort median 		598.7 582.1 49.0%
14 HBA1 protein_coding 2,167.7
bar=donor   line=cohort median 		2,133.6 1,960.7 55.2%
15 HBA2 protein_coding 1,182.0
bar=donor   line=cohort median 		1,142.2 1,083.5 55.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,337.5
bar=donor   line=cohort median 		6,862.1 6,938.4 37.6%
17 MT-CO2 protein_coding 6,196.3
bar=donor   line=cohort median 		6,023.6 5,810.8 59.3%
18 MT-ND1 protein_coding 3,322.3
bar=donor   line=cohort median 		3,656.3 3,718.2 35.0%
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