GSM6881255

Dataset: gse221521 • Sample: DR group RNA246 • Status: Diabetic retinopathy
◂ Prev All Donors Next ▸

Quality Control Metrics

14,175,695 Total counts Group median: 12,498,211 • 84.7%ile (↑ High)
27,579 Detected genes Group median: 27,368 • 79.5%ile (↑ High)
4 Mitochondrial fraction (%) Group median: 6 • 8.5%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

54.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.21
bar=donor   line=cohort median 		0.17 62.4%
FOXO3 Insulin/IGF-1 Signaling 25.71
bar=donor   line=cohort median 		12.92 99.7%
CETP Lipid Metabolism 0.37
bar=donor   line=cohort median 		0.40 41.7%
SIRT6 Sirtuin Family 3.62
bar=donor   line=cohort median 		3.67 45.9%
SIRT1 Sirtuin Family 3.58
bar=donor   line=cohort median 		3.48 57.8%
SIRT3 Sirtuin Family 0.81
bar=donor   line=cohort median 		1.10 10.1%
IGF1R Insulin/IGF-1 Signaling 3.89
bar=donor   line=cohort median 		4.33 45.3%
KLOTHO Anti-aging 0.09
bar=donor   line=cohort median 		0.06 61.9%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.06
bar=donor   line=cohort median 		0.07 45.9%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 63.5%
IRS2 Insulin/IGF-1 Signaling 132.33
bar=donor   line=cohort median 		35.28 99.2%
TP53 Tumor Suppression 3.22
bar=donor   line=cohort median 		3.83 29.3%
SHC1 Signal Transduction 8.48
bar=donor   line=cohort median 		8.77 39.1%
ACE Signal Transduction 0.45
bar=donor   line=cohort median 		0.39 60.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 12,469.8 101,288
2 MT-CO1 ENSG00000198804 protein_coding 5,266.2 115,113
3 MT-RNR2 ENSG00000210082 Mt_rRNA 5,072.5 112,102
4 FTL ENSG00000087086 protein_coding 4,523.3 55,849
5 MT-CO3 ENSG00000198938 protein_coding 3,827.8 42,541
6 MT-CO2 ENSG00000198712 protein_coding 3,701.7 35,892
7 MT-ND3 ENSG00000198840 protein_coding 2,970.4 14,569
8 MT-ATP8 ENSG00000228253 protein_coding 2,586.6 7,590
9 MT-ND4 ENSG00000198886 protein_coding 2,574.8 50,297
10 MT-ND1 ENSG00000198888 protein_coding 2,502.4 33,912

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,851.7
bar=donor   line=cohort median 		1,223.7 1,385.4 70.7%
2 S100A9 protein_coding 12,469.8
bar=donor   line=cohort median 		7,732.1 9,235.1 74.9%
3 IL1B protein_coding 4.2
bar=donor   line=cohort median 		4.9 6.1 28.8%
4 CXCL8 protein_coding 511.6
bar=donor   line=cohort median 		197.4 207.4 88.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 3.3
bar=donor   line=cohort median 		2.9 2.4 71.2%
6 FCGR3B protein_coding 188.8
bar=donor   line=cohort median 		108.9 129.3 73.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 708.6
bar=donor   line=cohort median 		581.4 706.2 51.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 30.6
bar=donor   line=cohort median 		51.6 56.4 8.0%
9 CD3E protein_coding 22.7
bar=donor   line=cohort median 		38.1 37.7 9.6%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 1.6
bar=donor   line=cohort median 		3.0 3.1 9.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 196.0
bar=donor   line=cohort median 		252.2 281.6 25.1%
12 GNLY protein_coding 64.1
bar=donor   line=cohort median 		58.9 70.7 39.6%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 161.8
bar=donor   line=cohort median 		585.0 582.1 10.6%
14 HBA1 protein_coding 429.9
bar=donor   line=cohort median 		1,960.4 1,960.7 4.9%
15 HBA2 protein_coding 274.8
bar=donor   line=cohort median 		1,080.5 1,083.5 6.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,266.2
bar=donor   line=cohort median 		6,740.9 6,938.4 16.8%
17 MT-CO2 protein_coding 3,701.7
bar=donor   line=cohort median 		5,693.7 5,810.8 8.0%
18 MT-ND1 protein_coding 2,502.4
bar=donor   line=cohort median 		3,876.8 3,718.2 13.7%
◂ Previous Donor Back to Donor List Next Donor ▸