GSM6881256

Dataset: gse221521 • Sample: Control group RNA252 • Status: Healthy control
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Quality Control Metrics

14,497,097 Total counts Group median: 12,762,148 • 88.9%ile (↑ High)
26,186 Detected genes Group median: 2,606 • 39.6%ile (≈ Median)
5 Mitochondrial fraction (%) Group median: 6 • 19.4%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

55.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.27
bar=donor   line=cohort median 		0.17 76.9%
FOXO3 Insulin/IGF-1 Signaling 10.78
bar=donor   line=cohort median 		12.92 27.7%
CETP Lipid Metabolism 0.42
bar=donor   line=cohort median 		0.40 56.2%
SIRT6 Sirtuin Family 5.14
bar=donor   line=cohort median 		3.67 94.6%
SIRT1 Sirtuin Family 2.86
bar=donor   line=cohort median 		3.48 21.5%
SIRT3 Sirtuin Family 1.28
bar=donor   line=cohort median 		1.10 76.4%
IGF1R Insulin/IGF-1 Signaling 1.82
bar=donor   line=cohort median 		4.33 16.3%
KLOTHO Anti-aging 0.14
bar=donor   line=cohort median 		0.06 84.7%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.03
bar=donor   line=cohort median 		0.07 26.7%
TERT Telomere Maintenance 0.04
bar=donor   line=cohort median 		0.01 83.7%
IRS2 Insulin/IGF-1 Signaling 21.97
bar=donor   line=cohort median 		35.28 20.5%
TP53 Tumor Suppression 4.58
bar=donor   line=cohort median 		3.83 69.2%
SHC1 Signal Transduction 8.50
bar=donor   line=cohort median 		8.77 40.2%
ACE Signal Transduction 0.63
bar=donor   line=cohort median 		0.39 84.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 16,040.0 133,242
2 FTL ENSG00000087086 protein_coding 6,232.6 78,699
3 MT-CO1 ENSG00000198804 protein_coding 6,194.6 138,478
4 MT-CO2 ENSG00000198712 protein_coding 6,095.6 60,444
5 MT-CO3 ENSG00000198938 protein_coding 5,918.7 67,270
6 MT-RNR2 ENSG00000210082 Mt_rRNA 5,446.6 123,098
7 RPS28P7 ENSG00000227097 processed_pseudogene 3,781.4 11,512
8 HBA1 ENSG00000206172 protein_coding 3,705.4 92,395
9 AC005912.1 ENSG00000227081 processed_pseudogene 3,596.9 13,297
10 RPL13AP5 ENSG00000236552 processed_pseudogene 3,474.3 30,825

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,745.3
bar=donor   line=cohort median 		1,535.8 1,385.4 91.5%
2 S100A9 protein_coding 16,040.0
bar=donor   line=cohort median 		10,851.3 9,235.1 86.8%
3 IL1B protein_coding 4.5
bar=donor   line=cohort median 		5.6 6.1 33.9%
4 CXCL8 protein_coding 225.4
bar=donor   line=cohort median 		220.4 207.4 53.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 11.8
bar=donor   line=cohort median 		1.7 2.4 97.7%
6 FCGR3B protein_coding 159.4
bar=donor   line=cohort median 		145.0 129.3 63.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,532.4
bar=donor   line=cohort median 		709.1 706.2 90.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 90.6
bar=donor   line=cohort median 		66.1 56.4 85.2%
9 CD3E protein_coding 41.3
bar=donor   line=cohort median 		37.6 37.7 60.9%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.3
bar=donor   line=cohort median 		3.1 3.1 28.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 281.6
bar=donor   line=cohort median 		302.3 281.6 50.0%
12 GNLY protein_coding 48.8
bar=donor   line=cohort median 		80.1 70.7 25.6%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,800.0
bar=donor   line=cohort median 		598.7 582.1 89.4%
14 HBA1 protein_coding 3,705.4
bar=donor   line=cohort median 		2,133.6 1,960.7 70.7%
15 HBA2 protein_coding 2,070.1
bar=donor   line=cohort median 		1,142.2 1,083.5 72.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,194.6
bar=donor   line=cohort median 		6,862.1 6,938.4 34.5%
17 MT-CO2 protein_coding 6,095.6
bar=donor   line=cohort median 		6,023.6 5,810.8 55.7%
18 MT-ND1 protein_coding 2,925.8
bar=donor   line=cohort median 		3,656.3 3,718.2 23.1%
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