GSM6881258

Dataset: gse221521 • Sample: DR group RNA253 • Status: Diabetic retinopathy
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Quality Control Metrics

12,328,229 Total counts Group median: 12,498,211 • 38.6%ile (≈ Median)
26,934 Detected genes Group median: 27,368 • 64.0%ile (≈ Median)
5 Mitochondrial fraction (%) Group median: 6 • 27.2%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

53.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.19
bar=donor   line=cohort median 		0.17 59.8%
FOXO3 Insulin/IGF-1 Signaling 15.92
bar=donor   line=cohort median 		12.92 72.3%
CETP Lipid Metabolism 0.50
bar=donor   line=cohort median 		0.40 68.1%
SIRT6 Sirtuin Family 3.98
bar=donor   line=cohort median 		3.67 64.5%
SIRT1 Sirtuin Family 3.54
bar=donor   line=cohort median 		3.48 55.2%
SIRT3 Sirtuin Family 0.95
bar=donor   line=cohort median 		1.10 23.6%
IGF1R Insulin/IGF-1 Signaling 5.49
bar=donor   line=cohort median 		4.33 69.7%
KLOTHO Anti-aging 0.02
bar=donor   line=cohort median 		0.06 22.0%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.03
bar=donor   line=cohort median 		0.07 31.4%
TERT Telomere Maintenance 0.03
bar=donor   line=cohort median 		0.01 69.7%
IRS2 Insulin/IGF-1 Signaling 49.66
bar=donor   line=cohort median 		35.28 71.8%
TP53 Tumor Suppression 4.28
bar=donor   line=cohort median 		3.83 62.4%
SHC1 Signal Transduction 9.19
bar=donor   line=cohort median 		8.77 63.5%
ACE Signal Transduction 0.25
bar=donor   line=cohort median 		0.39 26.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 11,232.2 79,345
2 MT-CO1 ENSG00000198804 protein_coding 7,337.5 139,487
3 MT-CO3 ENSG00000198938 protein_coding 5,990.7 57,902
4 MT-RNR2 ENSG00000210082 Mt_rRNA 5,717.6 109,891
5 MT-CO2 ENSG00000198712 protein_coding 5,693.7 48,012
6 FTL ENSG00000087086 protein_coding 4,666.5 50,108
7 MT-ND4 ENSG00000198886 protein_coding 3,899.1 66,239
8 MT-ND1 ENSG00000198888 protein_coding 3,340.0 39,365
9 MT-ATP8 ENSG00000228253 protein_coding 3,064.3 7,820
10 MT-ND4L ENSG00000212907 protein_coding 3,017.4 11,048

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,445.3
bar=donor   line=cohort median 		1,223.7 1,385.4 52.6%
2 S100A9 protein_coding 11,232.2
bar=donor   line=cohort median 		7,732.1 9,235.1 64.0%
3 IL1B protein_coding 6.6
bar=donor   line=cohort median 		4.9 6.1 56.7%
4 CXCL8 protein_coding 340.0
bar=donor   line=cohort median 		197.4 207.4 74.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 4.0
bar=donor   line=cohort median 		2.9 2.4 76.4%
6 FCGR3B protein_coding 229.3
bar=donor   line=cohort median 		108.9 129.3 85.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,013.4
bar=donor   line=cohort median 		581.4 706.2 73.3%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 28.2
bar=donor   line=cohort median 		51.6 56.4 6.0%
9 CD3E protein_coding 20.4
bar=donor   line=cohort median 		38.1 37.7 6.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 5.0
bar=donor   line=cohort median 		3.0 3.1 82.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 215.7
bar=donor   line=cohort median 		252.2 281.6 27.7%
12 GNLY protein_coding 68.7
bar=donor   line=cohort median 		58.9 70.7 45.3%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 177.1
bar=donor   line=cohort median 		585.0 582.1 12.2%
14 HBA1 protein_coding 532.5
bar=donor   line=cohort median 		1,960.4 1,960.7 7.5%
15 HBA2 protein_coding 282.4
bar=donor   line=cohort median 		1,080.5 1,083.5 7.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,337.5
bar=donor   line=cohort median 		6,740.9 6,938.4 56.7%
17 MT-CO2 protein_coding 5,693.7
bar=donor   line=cohort median 		5,693.7 5,810.8 46.4%
18 MT-ND1 protein_coding 3,340.0
bar=donor   line=cohort median 		3,876.8 3,718.2 35.5%
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