GSM6881259

Dataset: gse221521 • Sample: Control group RNA257 • Status: Healthy control
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Quality Control Metrics

11,846,867 Total counts Group median: 12,762,148 • 22.5%ile (↓ Low)
26,526 Detected genes Group median: 2,606 • 52.1%ile (≈ Median)
5 Mitochondrial fraction (%) Group median: 6 • 29.3%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

51.5Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.07
bar=donor   line=cohort median 		0.17 20.5%
FOXO3 Insulin/IGF-1 Signaling 15.63
bar=donor   line=cohort median 		12.92 70.7%
CETP Lipid Metabolism 0.26
bar=donor   line=cohort median 		0.40 19.4%
SIRT6 Sirtuin Family 3.63
bar=donor   line=cohort median 		3.67 47.4%
SIRT1 Sirtuin Family 3.63
bar=donor   line=cohort median 		3.48 60.4%
SIRT3 Sirtuin Family 0.97
bar=donor   line=cohort median 		1.10 26.2%
IGF1R Insulin/IGF-1 Signaling 8.03
bar=donor   line=cohort median 		4.33 95.6%
KLOTHO Anti-aging 0.09
bar=donor   line=cohort median 		0.06 65.5%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.02
bar=donor   line=cohort median 		0.07 25.1%
TERT Telomere Maintenance 0.03
bar=donor   line=cohort median 		0.01 73.3%
IRS2 Insulin/IGF-1 Signaling 45.94
bar=donor   line=cohort median 		35.28 65.5%
TP53 Tumor Suppression 3.39
bar=donor   line=cohort median 		3.83 33.9%
SHC1 Signal Transduction 9.32
bar=donor   line=cohort median 		8.77 68.1%
ACE Signal Transduction 0.40
bar=donor   line=cohort median 		0.39 51.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 9,837.6 66,780
2 MT-CO1 ENSG00000198804 protein_coding 6,821.2 124,608
3 MT-RNR2 ENSG00000210082 Mt_rRNA 6,189.0 114,306
4 MT-CO3 ENSG00000198938 protein_coding 5,690.0 52,848
5 MT-CO2 ENSG00000198712 protein_coding 5,577.1 45,193
6 FTL ENSG00000087086 protein_coding 4,242.6 43,778
7 MT-ND4 ENSG00000198886 protein_coding 4,153.2 67,801
8 MT-ATP8 ENSG00000228253 protein_coding 3,712.0 9,103
9 MT-ND4L ENSG00000212907 protein_coding 3,430.1 12,069
10 MT-ND1 ENSG00000198888 protein_coding 3,194.2 36,176

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,428.1
bar=donor   line=cohort median 		1,535.8 1,385.4 52.1%
2 S100A9 protein_coding 9,837.6
bar=donor   line=cohort median 		10,851.3 9,235.1 55.7%
3 IL1B protein_coding 6.9
bar=donor   line=cohort median 		5.6 6.1 59.8%
4 CXCL8 protein_coding 412.6
bar=donor   line=cohort median 		220.4 207.4 83.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.6
bar=donor   line=cohort median 		1.7 2.4 32.4%
6 FCGR3B protein_coding 142.4
bar=donor   line=cohort median 		145.0 129.3 54.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 870.9
bar=donor   line=cohort median 		709.1 706.2 65.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 48.9
bar=donor   line=cohort median 		66.1 56.4 37.6%
9 CD3E protein_coding 33.8
bar=donor   line=cohort median 		37.6 37.7 38.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 4.7
bar=donor   line=cohort median 		3.1 3.1 79.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 204.3
bar=donor   line=cohort median 		302.3 281.6 26.2%
12 GNLY protein_coding 70.1
bar=donor   line=cohort median 		80.1 70.7 49.0%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 191.9
bar=donor   line=cohort median 		598.7 582.1 13.2%
14 HBA1 protein_coding 623.3
bar=donor   line=cohort median 		2,133.6 1,960.7 12.2%
15 HBA2 protein_coding 378.4
bar=donor   line=cohort median 		1,142.2 1,083.5 14.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,821.2
bar=donor   line=cohort median 		6,862.1 6,938.4 45.9%
17 MT-CO2 protein_coding 5,577.1
bar=donor   line=cohort median 		6,023.6 5,810.8 42.7%
18 MT-ND1 protein_coding 3,194.2
bar=donor   line=cohort median 		3,656.3 3,718.2 31.9%
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