GSM6881260

Dataset: gse221521 • Sample: Control group RNA259 • Status: Healthy control
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Quality Control Metrics

12,839,914 Total counts Group median: 12,762,148 • 58.3%ile (≈ Median)
26,855 Detected genes Group median: 2,606 • 61.9%ile (≈ Median)
5 Mitochondrial fraction (%) Group median: 6 • 17.9%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

58.7Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.21
bar=donor   line=cohort median 		0.17 63.0%
FOXO3 Insulin/IGF-1 Signaling 11.62
bar=donor   line=cohort median 		12.92 37.1%
CETP Lipid Metabolism 0.51
bar=donor   line=cohort median 		0.40 70.7%
SIRT6 Sirtuin Family 3.68
bar=donor   line=cohort median 		3.67 50.5%
SIRT1 Sirtuin Family 3.23
bar=donor   line=cohort median 		3.48 37.1%
SIRT3 Sirtuin Family 1.01
bar=donor   line=cohort median 		1.10 34.5%
IGF1R Insulin/IGF-1 Signaling 7.18
bar=donor   line=cohort median 		4.33 89.9%
KLOTHO Anti-aging 0.13
bar=donor   line=cohort median 		0.06 82.6%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.09
bar=donor   line=cohort median 		0.07 64.5%
TERT Telomere Maintenance 0.04
bar=donor   line=cohort median 		0.01 84.7%
IRS2 Insulin/IGF-1 Signaling 26.63
bar=donor   line=cohort median 		35.28 33.9%
TP53 Tumor Suppression 4.93
bar=donor   line=cohort median 		3.83 77.5%
SHC1 Signal Transduction 9.28
bar=donor   line=cohort median 		8.77 66.6%
ACE Signal Transduction 0.33
bar=donor   line=cohort median 		0.39 40.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 11,524.2 84,787
2 MT-CO1 ENSG00000198804 protein_coding 6,885.7 136,331
3 FTL ENSG00000087086 protein_coding 5,772.5 64,557
4 MT-CO2 ENSG00000198712 protein_coding 5,448.4 47,851
5 MT-CO3 ENSG00000198938 protein_coding 5,437.5 54,737
6 MT-RNR2 ENSG00000210082 Mt_rRNA 5,148.4 103,058
7 MT-ND3 ENSG00000198840 protein_coding 3,889.6 17,280
8 MT-ND4 ENSG00000198886 protein_coding 3,296.5 58,327
9 MT-ATP8 ENSG00000228253 protein_coding 2,937.7 7,808
10 MT-TC ENSG00000210140 Mt_tRNA 2,937.1 2,489

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,030.9
bar=donor   line=cohort median 		1,535.8 1,385.4 78.0%
2 S100A9 protein_coding 11,524.2
bar=donor   line=cohort median 		10,851.3 9,235.1 65.5%
3 IL1B protein_coding 20.5
bar=donor   line=cohort median 		5.6 6.1 95.6%
4 CXCL8 protein_coding 297.9
bar=donor   line=cohort median 		220.4 207.4 66.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.6
bar=donor   line=cohort median 		1.7 2.4 31.3%
6 FCGR3B protein_coding 104.4
bar=donor   line=cohort median 		145.0 129.3 37.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 593.3
bar=donor   line=cohort median 		709.1 706.2 38.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 40.2
bar=donor   line=cohort median 		66.1 56.4 23.1%
9 CD3E protein_coding 27.4
bar=donor   line=cohort median 		37.6 37.7 20.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 6.7
bar=donor   line=cohort median 		3.1 3.1 90.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 244.1
bar=donor   line=cohort median 		302.3 281.6 36.5%
12 GNLY protein_coding 80.3
bar=donor   line=cohort median 		80.1 70.7 56.7%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 130.5
bar=donor   line=cohort median 		598.7 582.1 6.5%
14 HBA1 protein_coding 365.0
bar=donor   line=cohort median 		2,133.6 1,960.7 2.8%
15 HBA2 protein_coding 199.9
bar=donor   line=cohort median 		1,142.2 1,083.5 4.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,885.7
bar=donor   line=cohort median 		6,862.1 6,938.4 46.9%
17 MT-CO2 protein_coding 5,448.4
bar=donor   line=cohort median 		6,023.6 5,810.8 39.6%
18 MT-ND1 protein_coding 2,658.5
bar=donor   line=cohort median 		3,656.3 3,718.2 18.4%
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