GSM6881261

Dataset: gse221521 • Sample: DM group RNA26 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

11,671,764 Total counts Group median: 12,709,871 • 19.4%ile (↓ Low)
27,689 Detected genes Group median: 2,638 • 81.6%ile (↑ High)
9 Mitochondrial fraction (%) Group median: 6 • 86.3%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

47.5Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.11
bar=donor   line=cohort median 		0.17 36.5%
FOXO3 Insulin/IGF-1 Signaling 7.39
bar=donor   line=cohort median 		12.92 12.2%
CETP Lipid Metabolism 0.55
bar=donor   line=cohort median 		0.40 75.9%
SIRT6 Sirtuin Family 2.87
bar=donor   line=cohort median 		3.67 14.8%
SIRT1 Sirtuin Family 5.15
bar=donor   line=cohort median 		3.48 91.5%
SIRT3 Sirtuin Family 1.31
bar=donor   line=cohort median 		1.10 80.6%
IGF1R Insulin/IGF-1 Signaling 3.33
bar=donor   line=cohort median 		4.33 37.6%
KLOTHO Anti-aging 0.04
bar=donor   line=cohort median 		0.06 32.9%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.34
bar=donor   line=cohort median 		0.01 99.7%
IRS2 Insulin/IGF-1 Signaling 37.83
bar=donor   line=cohort median 		35.28 56.2%
TP53 Tumor Suppression 3.98
bar=donor   line=cohort median 		3.83 55.2%
SHC1 Signal Transduction 8.36
bar=donor   line=cohort median 		8.77 35.0%
ACE Signal Transduction 0.25
bar=donor   line=cohort median 		0.39 25.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-CO1 ENSG00000198804 protein_coding 14,760.2 265,652
2 MT-CO2 ENSG00000198712 protein_coding 10,936.3 87,310
3 MT-ATP6 ENSG00000198899 protein_coding 10,689.6 84,966
4 MT-CO3 ENSG00000198938 protein_coding 8,201.9 75,053
5 MT-ND4 ENSG00000198886 protein_coding 7,541.5 121,295
6 MT-ATP8 ENSG00000228253 protein_coding 6,617.0 15,987
7 MT-ND4L ENSG00000212907 protein_coding 6,053.6 20,985
8 MT-CYB ENSG00000198727 protein_coding 4,699.5 62,585
9 MT-ND1 ENSG00000198888 protein_coding 4,513.9 50,367
10 MT-RNR2 ENSG00000210082 Mt_rRNA 4,106.1 74,716

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 588.0
bar=donor   line=cohort median 		1,568.6 1,385.4 9.1%
2 S100A9 protein_coding 3,208.3
bar=donor   line=cohort median 		10,144.6 9,235.1 8.0%
3 IL1B protein_coding 1.7
bar=donor   line=cohort median 		6.9 6.1 8.0%
4 CXCL8 protein_coding 192.8
bar=donor   line=cohort median 		225.8 207.4 43.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.7
bar=donor   line=cohort median 		2.2 2.4 59.3%
6 FCGR3B protein_coding 57.9
bar=donor   line=cohort median 		157.0 129.3 12.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 325.5
bar=donor   line=cohort median 		802.6 706.2 13.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 15.6
bar=donor   line=cohort median 		56.8 56.4 1.3%
9 CD3E protein_coding 12.8
bar=donor   line=cohort median 		36.9 37.7 1.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 66.8
bar=donor   line=cohort median 		3.2 3.1 99.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 55.4
bar=donor   line=cohort median 		296.3 281.6 0.8%
12 GNLY protein_coding 24.3
bar=donor   line=cohort median 		77.5 70.7 5.4%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 66.9
bar=donor   line=cohort median 		509.6 582.1 1.8%
14 HBA1 protein_coding 260.5
bar=donor   line=cohort median 		1,931.5 1,960.7 1.8%
15 HBA2 protein_coding 89.7
bar=donor   line=cohort median 		1,068.0 1,083.5 0.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 14,760.2
bar=donor   line=cohort median 		7,011.1 6,938.4 99.2%
17 MT-CO2 protein_coding 10,936.3
bar=donor   line=cohort median 		5,968.9 5,810.8 95.1%
18 MT-ND1 protein_coding 4,513.9
bar=donor   line=cohort median 		3,670.4 3,718.2 72.8%
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