GSM6881262

Dataset: gse221521 • Sample: Control group RNA267 • Status: Healthy control
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Quality Control Metrics

13,334,996 Total counts Group median: 12,762,148 • 75.4%ile (↑ High)
27,087 Detected genes Group median: 2,606 • 68.7%ile (≈ Median)
5 Mitochondrial fraction (%) Group median: 6 • 18.4%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

53.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.32
bar=donor   line=cohort median 		0.17 85.8%
FOXO3 Insulin/IGF-1 Signaling 16.23
bar=donor   line=cohort median 		12.92 74.4%
CETP Lipid Metabolism 0.18
bar=donor   line=cohort median 		0.40 6.0%
SIRT6 Sirtuin Family 3.62
bar=donor   line=cohort median 		3.67 46.4%
SIRT1 Sirtuin Family 3.90
bar=donor   line=cohort median 		3.48 68.1%
SIRT3 Sirtuin Family 0.94
bar=donor   line=cohort median 		1.10 22.0%
IGF1R Insulin/IGF-1 Signaling 3.28
bar=donor   line=cohort median 		4.33 36.5%
KLOTHO Anti-aging 0.01
bar=donor   line=cohort median 		0.06 11.7%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.08
bar=donor   line=cohort median 		0.07 54.2%
TERT Telomere Maintenance 0.06
bar=donor   line=cohort median 		0.01 91.5%
IRS2 Insulin/IGF-1 Signaling 66.86
bar=donor   line=cohort median 		35.28 87.3%
TP53 Tumor Suppression 3.94
bar=donor   line=cohort median 		3.83 53.1%
SHC1 Signal Transduction 8.40
bar=donor   line=cohort median 		8.77 36.5%
ACE Signal Transduction 0.70
bar=donor   line=cohort median 		0.39 85.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 13,434.1 102,649
2 MT-RNR2 ENSG00000210082 Mt_rRNA 6,539.7 135,956
3 FTL ENSG00000087086 protein_coding 6,422.2 74,592
4 MT-CO1 ENSG00000198804 protein_coding 6,013.0 123,643
5 MT-CO3 ENSG00000198938 protein_coding 5,348.2 55,913
6 MT-CO2 ENSG00000198712 protein_coding 4,662.1 42,524
7 MT-ND3 ENSG00000198840 protein_coding 3,261.4 15,048
8 MT-ND4 ENSG00000198886 protein_coding 3,199.9 58,801
9 MT-RNR1 ENSG00000211459 Mt_rRNA 3,112.4 39,595
10 EEF1A1P5 ENSG00000196205 processed_pseudogene 2,891.4 53,556

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,369.4
bar=donor   line=cohort median 		1,535.8 1,385.4 47.9%
2 S100A9 protein_coding 13,434.1
bar=donor   line=cohort median 		10,851.3 9,235.1 77.5%
3 IL1B protein_coding 6.1
bar=donor   line=cohort median 		5.6 6.1 51.0%
4 CXCL8 protein_coding 386.3
bar=donor   line=cohort median 		220.4 207.4 79.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 3.7
bar=donor   line=cohort median 		1.7 2.4 74.4%
6 FCGR3B protein_coding 118.6
bar=donor   line=cohort median 		145.0 129.3 41.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,364.5
bar=donor   line=cohort median 		709.1 706.2 88.3%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 49.3
bar=donor   line=cohort median 		66.1 56.4 39.1%
9 CD3E protein_coding 33.1
bar=donor   line=cohort median 		37.6 37.7 35.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.6
bar=donor   line=cohort median 		3.1 3.1 35.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 183.6
bar=donor   line=cohort median 		302.3 281.6 21.5%
12 GNLY protein_coding 40.3
bar=donor   line=cohort median 		80.1 70.7 17.4%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 229.9
bar=donor   line=cohort median 		598.7 582.1 18.4%
14 HBA1 protein_coding 551.1
bar=donor   line=cohort median 		2,133.6 1,960.7 9.1%
15 HBA2 protein_coding 312.3
bar=donor   line=cohort median 		1,142.2 1,083.5 10.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,013.0
bar=donor   line=cohort median 		6,862.1 6,938.4 30.8%
17 MT-CO2 protein_coding 4,662.1
bar=donor   line=cohort median 		6,023.6 5,810.8 19.9%
18 MT-ND1 protein_coding 2,610.2
bar=donor   line=cohort median 		3,656.3 3,718.2 16.3%
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