GSM6881264

Dataset: gse221521 • Sample: Control group RNA275 • Status: Healthy control
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Quality Control Metrics

11,893,251 Total counts Group median: 12,762,148 • 24.1%ile (↓ Low)
25,484 Detected genes Group median: 2,606 • 18.9%ile (↓ Low)
7 Mitochondrial fraction (%) Group median: 6 • 64.0%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

44.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.09
bar=donor   line=cohort median 		0.17 29.3%
FOXO3 Insulin/IGF-1 Signaling 18.55
bar=donor   line=cohort median 		12.92 88.3%
CETP Lipid Metabolism 0.54
bar=donor   line=cohort median 		0.40 74.4%
SIRT6 Sirtuin Family 4.29
bar=donor   line=cohort median 		3.67 78.0%
SIRT1 Sirtuin Family 3.95
bar=donor   line=cohort median 		3.48 68.7%
SIRT3 Sirtuin Family 1.02
bar=donor   line=cohort median 		1.10 35.0%
IGF1R Insulin/IGF-1 Signaling 4.33
bar=donor   line=cohort median 		4.33 50.0%
KLOTHO Anti-aging 0.00
bar=donor   line=cohort median 		0.06 5.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.01
bar=donor   line=cohort median 		0.01 46.9%
IRS2 Insulin/IGF-1 Signaling 47.66
bar=donor   line=cohort median 		35.28 68.1%
TP53 Tumor Suppression 3.26
bar=donor   line=cohort median 		3.83 30.3%
SHC1 Signal Transduction 7.99
bar=donor   line=cohort median 		8.77 20.5%
ACE Signal Transduction 0.16
bar=donor   line=cohort median 		0.39 9.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 10,824.5 200,703
2 S100A9 ENSG00000163220 protein_coding 9,778.5 66,639
3 MT-CO1 ENSG00000198804 protein_coding 7,462.0 136,849
4 MT-RNR1 ENSG00000211459 Mt_rRNA 6,637.4 75,309
5 MT-CO2 ENSG00000198712 protein_coding 6,259.9 50,924
6 FTL ENSG00000087086 protein_coding 6,023.4 62,397
7 MT-CO3 ENSG00000198938 protein_coding 5,881.3 54,839
8 MT-ND1 ENSG00000198888 protein_coding 4,664.3 53,033
9 MT-ND4 ENSG00000198886 protein_coding 3,931.0 64,424
10 HBA1 ENSG00000206172 protein_coding 3,786.3 77,454

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,334.3
bar=donor   line=cohort median 		1,535.8 1,385.4 46.4%
2 S100A9 protein_coding 9,778.5
bar=donor   line=cohort median 		10,851.3 9,235.1 54.1%
3 IL1B protein_coding 4.5
bar=donor   line=cohort median 		5.6 6.1 35.0%
4 CXCL8 protein_coding 1,017.1
bar=donor   line=cohort median 		220.4 207.4 99.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 3.3
bar=donor   line=cohort median 		1.7 2.4 70.7%
6 FCGR3B protein_coding 271.7
bar=donor   line=cohort median 		145.0 129.3 92.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 705.9
bar=donor   line=cohort median 		709.1 706.2 49.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 52.5
bar=donor   line=cohort median 		66.1 56.4 45.9%
9 CD3E protein_coding 52.8
bar=donor   line=cohort median 		37.6 37.7 81.6%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 1.7
bar=donor   line=cohort median 		3.1 3.1 12.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 262.3
bar=donor   line=cohort median 		302.3 281.6 42.7%
12 GNLY protein_coding 66.9
bar=donor   line=cohort median 		80.1 70.7 42.2%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 687.1
bar=donor   line=cohort median 		598.7 582.1 57.3%
14 HBA1 protein_coding 3,786.3
bar=donor   line=cohort median 		2,133.6 1,960.7 71.8%
15 HBA2 protein_coding 1,597.4
bar=donor   line=cohort median 		1,142.2 1,083.5 64.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,462.0
bar=donor   line=cohort median 		6,862.1 6,938.4 58.8%
17 MT-CO2 protein_coding 6,259.9
bar=donor   line=cohort median 		6,023.6 5,810.8 61.4%
18 MT-ND1 protein_coding 4,664.3
bar=donor   line=cohort median 		3,656.3 3,718.2 74.9%
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