GSM6881265

Dataset: gse221521 • Sample: DM group RNA277 • Status: Diabetes mellitus without diabetic retinopathy
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Quality Control Metrics

10,292,881 Total counts Group median: 12,709,871 • 6.0%ile (↓ Low)
24,554 Detected genes Group median: 2,638 • 8.5%ile (↓ Low)
8 Mitochondrial fraction (%) Group median: 6 • 81.6%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

44.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.23
bar=donor   line=cohort median 		0.17 70.2%
FOXO3 Insulin/IGF-1 Signaling 10.18
bar=donor   line=cohort median 		12.92 23.1%
CETP Lipid Metabolism 0.28
bar=donor   line=cohort median 		0.40 21.0%
SIRT6 Sirtuin Family 4.14
bar=donor   line=cohort median 		3.67 73.8%
SIRT1 Sirtuin Family 2.99
bar=donor   line=cohort median 		3.48 26.2%
SIRT3 Sirtuin Family 0.96
bar=donor   line=cohort median 		1.10 25.7%
IGF1R Insulin/IGF-1 Signaling 4.75
bar=donor   line=cohort median 		4.33 54.7%
KLOTHO Anti-aging 0.00
bar=donor   line=cohort median 		0.06 5.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.08
bar=donor   line=cohort median 		0.07 55.7%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 25.12
bar=donor   line=cohort median 		35.28 28.2%
TP53 Tumor Suppression 3.35
bar=donor   line=cohort median 		3.83 32.4%
SHC1 Signal Transduction 9.62
bar=donor   line=cohort median 		8.77 78.5%
ACE Signal Transduction 1.58
bar=donor   line=cohort median 		0.39 99.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 10,583.1 169,823
2 S100A9 ENSG00000163220 protein_coding 9,527.9 56,194
3 MT-CO2 ENSG00000198712 protein_coding 9,460.2 66,603
4 MT-CO3 ENSG00000198938 protein_coding 8,743.5 70,557
5 MT-CO1 ENSG00000198804 protein_coding 8,110.3 128,724
6 MT-ND3 ENSG00000198840 protein_coding 7,328.4 26,099
7 MT-ND1 ENSG00000198888 protein_coding 6,123.5 60,255
8 MT-RNR1 ENSG00000211459 Mt_rRNA 5,153.6 50,605
9 MT-ATP8 ENSG00000228253 protein_coding 4,852.1 10,338
10 MT-ND2 ENSG00000198763 protein_coding 4,539.0 48,682

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,480.5
bar=donor   line=cohort median 		1,568.6 1,385.4 53.6%
2 S100A9 protein_coding 9,527.9
bar=donor   line=cohort median 		10,144.6 9,235.1 51.6%
3 IL1B protein_coding 2.3
bar=donor   line=cohort median 		6.9 6.1 11.1%
4 CXCL8 protein_coding 156.7
bar=donor   line=cohort median 		225.8 207.4 32.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 3.1
bar=donor   line=cohort median 		2.2 2.4 67.1%
6 FCGR3B protein_coding 101.0
bar=donor   line=cohort median 		157.0 129.3 34.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 400.2
bar=donor   line=cohort median 		802.6 706.2 17.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 114.1
bar=donor   line=cohort median 		56.8 56.4 92.5%
9 CD3E protein_coding 60.1
bar=donor   line=cohort median 		36.9 37.7 87.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 5.6
bar=donor   line=cohort median 		3.2 3.1 87.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 393.1
bar=donor   line=cohort median 		296.3 281.6 76.4%
12 GNLY protein_coding 107.9
bar=donor   line=cohort median 		77.5 70.7 75.4%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 608.1
bar=donor   line=cohort median 		509.6 582.1 52.1%
14 HBA1 protein_coding 2,642.9
bar=donor   line=cohort median 		1,931.5 1,960.7 62.4%
15 HBA2 protein_coding 1,703.9
bar=donor   line=cohort median 		1,068.0 1,083.5 66.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,110.3
bar=donor   line=cohort median 		7,011.1 6,938.4 69.2%
17 MT-CO2 protein_coding 9,460.2
bar=donor   line=cohort median 		5,968.9 5,810.8 89.4%
18 MT-ND1 protein_coding 6,123.5
bar=donor   line=cohort median 		3,670.4 3,718.2 89.4%
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